Testing Information

Testing Status of Agents at NTP

n-Butyl chloride

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http://ntp.niehs.nih.gov/go/TS-10089-H

CASRN: 109-69-3

Formula: C4-H9-CL

Synonyms/Common Names:

  • 1-CHLOROBUTANE

Known Uses:

BUTYLATING AGENT IN ORGANIC SYNTHESIS, SOLVENT, VETERINARY ANTIHELMINTIC (HSDB 1990)

Short-Term Toxicity

  • 14-Day (Gavage)  (C06155A) Completed 
    • NTIS No. PB86-218526  (Peer Review 08/14/1985)
      Citation: Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CAS No. 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1; Mice: B6C3F1
  • 13-Week (Gavage)  (C06155A) Completed 
    • NTIS No. PB86-218526  (Peer Review 08/14/1985)
      Citation: Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CAS No. 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1; Mice: B6C3F1
    • Dose: R: 0,30,500 M: 0,60,1000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 108-WEEK (Gavage)  (C06155A) Report Complete 
    • TR-312 (NTIS No. PB86-218526)  (Peer Review 08/14/1985)
      Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CAS No. 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,60,120 M: 0,500,1000 MG/KG/50 PER GROUP
  • 2-YEAR (Gavage)  (C06155A) Report Complete 
    • TR-312 (NTIS No. PB86-218526)  (Peer Review 08/14/1985)
      Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CAS No. 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,60,120 M: 0,500,1000 MG/KG/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (297558) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Mouse Lymphoma  (048570) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Inadequate Study 
  • Salmonella  (684822) Completed 
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Negative 
  • Salmonella  (767736) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Negative 

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Web page last updated on January 22, 2009