National Toxicology Program

CASRN: 60-13-9

Related: D-AMPHETAMINE SULFATE (CAS 51-63-8)

Formula: C9 H13 N.1/2H2 O4 S

Synonyms/Common Names:

• ALPHA-METHYL-BENZENEETHANAMINE(+-)-SULFATE (2:1) (9CI)

Known Uses:

TREATMENT OF NARCOLEPSY AND WEIGHT PROBLEMS; FOR BEHAVIOR DISORDERS IN CHILDREN

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C55710) Completed 
  • NTIS No. PB92-107978  (Peer Review 04/25/1990)
    Citation: Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CAS No. 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C55710) Completed 
  • NTIS No. PB92-107978  (Peer Review 04/25/1990)
    Citation: Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CAS No. 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,6.25,100, M: 0,25,400 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C55710) Report Complete 
  • TR-387 (NTIS No. PB92-107978)  (Peer Review 04/25/1990)
    Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CAS No. 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R&M:0,20,100 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (381641) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Salmonella  (561780) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Inconclusive