National Toxicology Program

CASRN: 81-49-2

Formula: C14 H7 BR2 N O2

Synonyms/Common Names:

• ADBAC
• 1-AMINO-2,4-DIBROMO-9,10-ANTHRACENEDIONE

Known Uses:

IN MANUFACTURE OF DYES. (3)

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C55458) Completed 
  • NTIS No. PB97-116636  (Peer Review 06/21/1994)
    Citation: Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CAS No. 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-WEEK (Dosed-Feed)  (C55458) Completed 
  • NTIS No. PB97-116636  (Peer Review 06/21/1994)
    Citation: Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CAS No. 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,2500,50000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C55458) Report Complete 
  • TR-383 (NTIS No. PB97-116636)  (Peer Review 06/21/1994)
    Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CAS No. 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0,.2,.5,1.0,2.0, M: 0,1.0,2.0 %/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0212) Completed 
  • M Rats: F344/N; M Rats: F344/N
  • Dose: IV:O.4 MG/KG;PO:2,23,118,814,1473 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (438792) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Inconclusive 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (905842) Completed 
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella  (685556) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive