Testing Information

Testing Status of Agents at NTP

2-Mercaptobenzothiazole

Print this pageFriendly URL

http://ntp.niehs.nih.gov/go/TS-10073-C

CASRN: 149-30-4

Formula: C7-H5-N-S2

Synonyms/Common Names:

  • 2(3H)-BENZOTHIAZOLETHIONE (9CI)
  • MBT

Known Uses:

RUBBER VULCANIZATION ACCELERATOR. SALTS USED AS FUNGICIDE. CORROSION INHIBITOR FOR COPPER IN AQUEOUS SYSTEMS,CUTTING OILS AND PETROLEUM PRODUCTS. ADDITIVE IN EXTREME-PRESSURE GREASES. (TDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56519) Completed 
    • NTIS No. PB88-245154  (Peer Review 03/04/1987)
      Citation: Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CAS No. 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56519) Completed 
    • NTIS No. PB88-245154  (Peer Review 03/04/1987)
      Citation: Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CAS No. 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,.1,10 MG/M3/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C56519) Report Complete 
    • TR-332 (NTIS No. PB88-245154)  (Peer Review 03/04/1987)
      Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CAS No. 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: FR: 0,188,375, MR&M: 0,375,750 MG/KG/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (748636) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Not Tested 
  • In Vitro Cytogenetics (CA/SCE)  (997320) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Not Tested 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma  (920542) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Positive 
  • Micronucleus  (A38881) Completed 
    • Rats: F344
    • Male Negative 
  • Micronucleus  (A62048) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (855075) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Inconclusive 
  • Salmonella  (876400) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM90003) Completed 
    • NTIS No. PB92-140383
      Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
    • Citation: SUMMARY (1-15)
    • F Mice: B6C3F1
    • Mice Female Positive 
    • Dose: 0, 1, 3, 7.5%

Back to top

Web page last updated on January 22, 2009