Testing Information

Testing Status of Agents at NTP

Bromoethane (ethyl bromide)

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CASRN: 74-96-4

Formula: C2-H5-BR

Synonyms/Common Names:

  • BROMOETHANE (9CI)
  • ETHYL BROMIDE

Known Uses:

CHEMICAL INTERMEDIATE FOR PHARMACEUTICALS. ETHYLATING AGENT IN ORGANIC SYNTHESIS. REFRIGERANT. GRAIN AND FRUIT FUMIGANT. (TDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C55481) Completed 
    • NTIS No. PB90-219445  (Peer Review 10/03/1988)
      Citation: Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CAS No. 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C55481) Completed 
    • NTIS No. PB90-219445  (Peer Review 10/03/1988)
      Citation: Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CAS No. 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,100,1600 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Inhalation)  (C55481) Report Complete 
    • TR-363 (NTIS No. PB90-219445)  (Peer Review 10/03/1988)
      Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CAS No. 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0,100,200,400 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (496296) Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Salmonella  (024373) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (811571) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

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Web page last updated on January 22, 2009