National Toxicology Program

CASRN: 100-51-6

Formula: C7-H8-O

Synonyms/Common Names:

• BENZENEMETHANOL (9CI)

Known Uses:

MANUFACTURE OF OTHER BENZYL COMPOUNDS. SOLVENT FOR GELATIN, CASEIN, CELLULOSE ACETATE & SHELLAC. USED IN PERFUMERY & FLAVORING. VIRUCIDE IN LOTIONS. LACQUER SOLVENT. PLASTICIZER. PRESERVATIVE IN OPHTHALMIC PREPARATIONS.

Short-Term Toxicity

• 14-Day (Gavage)  (C06111) Completed 
  • NTIS No. PB90-110206  (Peer Review 11/06/1987)
    Citation: Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C06111) Completed 
  • NTIS No. PB90-110206  (Peer Review 11/06/1987)
    Citation: Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,50,800 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C06111) Report Complete 
  • TR-343 (NTIS No. PB90-110206)  (Peer Review 11/06/1987)
    Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,200,400, M: 0,100,200 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (944840) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Weakly Positive 
• Drosophila  (419402) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (464779) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Inconclusive 
• Salmonella  (597306) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 

Organ Systems Toxicity

• 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0049A) Completed 
  • NTIS No. PB83-258616
    Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
  • F Mice: Swiss
  • Dose: 750 MG/KG BD WT
• GD 6-15 (COPULATORY PLUG = GD 0) Short-Term in vivo Repro. Tox. (Gavage)  (T0049B) Completed 
  • F Mice: Swiss