Testing Information

Testing Status of Agents at NTP

Naphthalene

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http://ntp.niehs.nih.gov/go/TS-10046-P

CASRN: 91-20-3

Formula: C10-H8

Synonyms/Common Names:

  • NAPTHENE

Known Uses:

CHEMICAL INTERMEDIATE, INSECTICIDES, REPELLANTS, ANTISEPTIC, VERMICIDE, SYNTHETIC RESINS; IN VARIOUS COMMERCICAL MOTH REPELLANTS AND TOILET BOWL CLEANERS; TOPICALLY IN VETERINARY MEDICINE. PREPARED FROM COAL TAR.

Long-Term Carcinogenicity

  • 2-YEAR (Inhalation)  (C52904B) Report Complete 
    • TR-410 (NTIS No. PB92-224260/AS)  (Peer Review 03/11/1991)
      Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in B6C3F1 Mice (Inhalation Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: 0,10 (75 mice/sex/group),30 (150 mice/sex/group) PPM
  • 2-YEAR (Inhalation)  (C52904C) Report Complete 
    • TR-500 (NTIS No. PB2001-103699)  (Peer Review 05/18/2000)
      Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in F344/N Rats (Inhalation Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: R: 0, 10, 30, OR 60 PPM; 58/SEX/GROUP

Special Studies

  • Toxicokinetic Study (Intravenous)  (S0571) Completed 
    • Citation: WILL BE PUBLISHED IN TWO YEAR TECHNICAL REPORT (C52904C)
    • M/F Rats: F344/N; M/F Mice: B6C3F1
    • Dose: SINGLE ADMINISTRATION IV RATS 3, 10, & 30 MG/KG; Mice 1, 3, and 10 mg/kg.
  • Toxicokinetic Study (Inhalation)  (S0606) Completed 
    • Citation: PART OF TWO YEAR TECHNICAL REPORT (SEE C52904C)
    • M/F Rats: F344/N
    • Dose: Rats: 10, 30, 60 ppm; 58/sex/group

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (040612) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Salmonella  (471098) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0038) Completed 
    • NTIS No. PB83-213017
      Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • F Mice: Swiss
    • Dose: 300 MG/KG BODY WT.
  • GD 6-15 Conventional Teratology (Gavage)  (TER91006) Completed 
    • NTIS No. PB92-135623
      Citation: Final Report on the Developmental Toxicity of Naphthalene in Sprague-Dawley (CD) Rats
    • Rats: Sprague Dawley
    • Rats Maternal ? 
    • Rats Fetal ? 
    • Dose: 0, 50, 150, 450 MG/KG/DAY
  • GD 6-19 Conventional Teratology (Gavage)  (TER91021) Completed 
    • NTIS No. PB92-219831
      Citation: Final Report on the Developmental Toxicity of Napthalene in New Zealand White Rabbits
    • F Rabbit: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 0, 20, 80, 120 MG/KG/DAY
  • GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP90014) Completed 
    • F Rats: Sprague Dawley
    • Dose: 0, 100, 400, 500, 600, OR 800 MG/KG
  • GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP90015) Completed 
    • F Rabbit: New Zealand White
    • Dose: 0, 75, 150, 300, OR 500 MG/KG

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Web page last updated on January 22, 2009