Testing Status of Agents at NTP
Naphthalene
CASRN: 91-20-3
Formula: C10-H8
Synonyms/Common Names:
- NAPTHENE
Known Uses:
CHEMICAL INTERMEDIATE, INSECTICIDES, REPELLANTS, ANTISEPTIC, VERMICIDE, SYNTHETIC RESINS; IN VARIOUS COMMERCICAL MOTH REPELLANTS AND TOILET BOWL CLEANERS; TOPICALLY IN VETERINARY MEDICINE. PREPARED FROM COAL TAR.
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C52904B) Report Complete
- TR-410 (NTIS No. PB92-224260/AS)
(Peer Review 03/11/1991)
Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice No Evidence
- Female Mice Some Evidence
- Dose: 0,10 (75 mice/sex/group),30 (150 mice/sex/group) PPM
- TR-410 (NTIS No. PB92-224260/AS)
(Peer Review 03/11/1991)
- 2-YEAR (Inhalation)
(C52904C) Report Complete
- TR-500 (NTIS No. PB2001-103699)
(Peer Review 05/18/2000)
Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in F344/N Rats (Inhalation Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Dose: R: 0, 10, 30, OR 60 PPM; 58/SEX/GROUP
- TR-500 (NTIS No. PB2001-103699)
(Peer Review 05/18/2000)
Special Studies
- Toxicokinetic Study (Intravenous)
(S0571) Completed
- Citation: WILL BE PUBLISHED IN TWO YEAR TECHNICAL REPORT (C52904C)
- M/F Rats: F344/N; M/F Mice: B6C3F1
- Dose: SINGLE ADMINISTRATION IV RATS 3, 10, & 30 MG/KG; Mice 1, 3, and 10 mg/kg.
- Toxicokinetic Study (Inhalation)
(S0606) Completed
- Citation: PART OF TWO YEAR TECHNICAL REPORT (SEE C52904C)
- M/F Rats: F344/N
- Dose: Rats: 10, 30, 60 ppm; 58/sex/group
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(040612) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Salmonella
(471098) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Organ Systems Toxicity
- 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)
(T0038) Completed
- NTIS No. PB83-213017
Citation: Screening of Priority Chemicals for Potential Reproductive Hazard - F Mice: Swiss
- Dose: 300 MG/KG BODY WT.
- NTIS No. PB83-213017
- GD 6-15 Conventional Teratology (Gavage)
(TER91006) Completed
- NTIS No. PB92-135623
Citation: Final Report on the Developmental Toxicity of Naphthalene in Sprague-Dawley (CD) Rats - Rats: Sprague Dawley
- Rats Maternal ?
- Rats Fetal ?
- Dose: 0, 50, 150, 450 MG/KG/DAY
- NTIS No. PB92-135623
- GD 6-19 Conventional Teratology (Gavage)
(TER91021) Completed
- NTIS No. PB92-219831
Citation: Final Report on the Developmental Toxicity of Napthalene in New Zealand White Rabbits - F Rabbit: New Zealand White
- Rabbits Maternal Negative
- Rabbits Fetal Negative
- Dose: 0, 20, 80, 120 MG/KG/DAY
- NTIS No. PB92-219831
- GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)
(TRP90014) Completed
- F Rats: Sprague Dawley
- Dose: 0, 100, 400, 500, 600, OR 800 MG/KG
- GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)
(TRP90015) Completed
- F Rabbit: New Zealand White
- Dose: 0, 75, 150, 300, OR 500 MG/KG
Web page last updated on January 22, 2009