National Toxicology Program

CASRN: 106-46-7

Related: 1,2-DICHLOROBENZENE (95-50-1) & 1,3-DICHLOROBENZENE (541-73-1)

Formula: C6-H4-CL2

Synonyms/Common Names:

• P-DICHLOROBENZENE

Known Uses:

INSECTICIDAL FUMIGANT, GERMICIDE, INTR IN MANUF. OF DICHLOROANILINE, DYES, IN PHARMACEUTICALS, DEODORANT FOR GARBAGE & RESTROOMS (HSDB 1990)

Short-Term Toxicity

• 14-Day (Gavage)  (C54955A) Completed 
  • NTIS No. PB87-208617  (Peer Review 03/26/1986)
    Citation: Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CAS No. 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C54955A) Completed 
  • NTIS No. PB87-208617  (Peer Review 03/26/1986)
    Citation: Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CAS No. 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,37.5,600, M: 0,84.4,900 MG/KG/60 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C54955A) Report Complete 
  • TR-319 (NTIS No. PB87-208617)  (Peer Review 03/26/1986)
    Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CAS No. 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats No Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: MR: 0,150,300 MG/KG, FR: 0,300,600 MG/KG, M: 0,300,600 MG/KG/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intraperitoneal Injection; Dosed-Water)  (S0064) Completed 
  • M Rats: F344/N; M Rats: F344/N

Genetic Toxicology

• Chromosome Aberrations  (576715) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (983738) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (465704) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
  •  Inconclusive 
• Micronucleus  (447196) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A90787) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (590003) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative