National Toxicology Program

CASRN: 10043-35-3

Formula: B-H3-O3

Synonyms/Common Names:

• BORACIC ACID

Known Uses:

WEATHERPROOFING WOOD. FIREPROOFING FABRICS. PRINTING AND DYEING. ASTRINGENT. ANTISEPTIC. IN COSMETIC POWDERS. IN MANUFACTURE OF CEMENTS, CROCKERY, GLASS, LEATHER, CARPETS, HATS AND SOAPS. (TDB)

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C56417) Completed 
  • NTIS No. PB88-213475  (Peer Review 03/26/1986)
    Citation: Toxicology and Carcinogenesis Studies of Boric Acid (CAS No. 10043-35-3) in B6C3F1 Mice (Feed Studies)
  • Mice: B6C3F1
• 13-WEEK (Dosed-Feed)  (C56417) Completed 
  • NTIS No. PB88-213475  (Peer Review 03/26/1986)
    Citation: Toxicology and Carcinogenesis Studies of Boric Acid (CAS No. 10043-35-3) in B6C3F1 Mice (Feed Studies)
  • Mice: B6C3F1
  • Dose: 0,1200,2000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C56417) Report Complete 
  • TR-324 (NTIS No. PB88-213475)  (Peer Review 03/26/1986)
    Toxicology and Carcinogenesis Studies of Boric Acid (CAS No. 10043-35-3) in B6C3F1 Mice (Feed Studies)
  • Mice: B6C3F1
  • Carcinogenesis Results
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: 0,2500,5000 PPM/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0787) Completed 
  • Citation: KU, W.W., CHAPIN, R.E., MOSEMAN, R.F., BRINK, R.E., PIERCE, K.D., AND ADAMS, K.Y. TISSUE DISPOSITION OF BORON IN MALE FISCHER RATS. TOXICOLOGY AND APPLIED PHARMACOLOGY 111, 145-151 (1991)
  • M Rats: F344/N
  • Dose: 9000 ppm (w/w) boric acid (1575 ppm boron)
• Mechanisms (Dosed-Feed)  (S0788) Completed 
  • Citation: KU, W.W., CHAPIN, R.E., WINE, R.N., AND GLADEN, B.C. TEXTICULAR TOXICITY OF BORIC ACID (BA): RELATIONSHIP OF DOSE TO LESION DEVELOPMENT AND RECOVERY IN THE F344 RAT. REPRODUCTIVE TOXICITY VOL7. PP, 305-319, 1993
  • M Rats: F344/N
  • Dose: 3000, 4500, 6000, 9000 ppm

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (153962) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (621739) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Negative 
• Salmonella  (683471) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (789471) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Inconclusive 

Organ Systems Toxicity

• 27 WEEKS Continuous Breeding (Dosed-Feed)  (RACB88034) Completed 
  • NTIS No. PB90-253808
    Citation: Reproductive Toxicity of Boric Acid in CD-1 Swiss Mice
  • M/F Mice: Swiss
  • Dose: N/A; 0,1000,4500,9000 PPM; 0,4500 PPM; 0,1000 PPM
• 10, 14, OR 21 DAYS Spermiation Inhibition (Dosed-Feed)  (RACB93162) Completed 
  • M Rats: F344/N
  • Dose: </= 9000 PPM
• GD 0-20 Conventional Teratology (Dosed-Feed)  (TER89027) Completed 
  • NTIS No. PB91-137588
    Citation: Final Report on the Developmental Toxicity Evaluation of Boric Acid Administered in Feed to Sprague-Dawley (CD) Rats on Gestational Days 0-20 or 6-15
  • F Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 0, .1, .2, .4, .8%
• GD 0-17 Conventional Teratology (Dosed-Feed)  (TER89028) Completed 
  • NTIS No. PB91-132332
    Citation: Final Report on the Developmental Toxicity Evaluation of Boric Acid Administered in Feed to CD-1 Mice on Gestational Days 0 to 17
  • F Mice: Swiss
  • Mice Maternal Positive 
  • Mice Fetal Positive 
  • Dose: 0, 0.1, 0.2, 0.4%
• GD 6-19 Conventional Teratology (Gavage)  (TER90003) Completed 
  • NTIS No. PB92-129550/AS
    Citation: Final Report on the Developmental Toxicity of Boric Acid in New Zealand White Rabbits
  • F Rabbit: New Zealand White
  • Rabbits Maternal Positive 
  • Rabbits Fetal Positive 
  • Dose: 0, 62.5, 125, 250 MG/KG/DAY
• GD 14 TO 17 Conventional Teratology (Dosed-Feed)  (TER90123) Completed 
  • NTIS No. PB95-137485
    Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 14-17
  • NTIS No. PB95-137758
    Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 14-17
  • F Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 0, 0.8, 1.6, 2.4% AND PAIR FED CONTROL FOR 2.4%
• GD 6 TO 15 Conventional Teratology (Dosed-Feed)  (TER93138) Completed 
  • NTIS No. PB95-149399
    Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 6-15
  • NTIS No. PB95-149407
    Citation: CNS Developmental Toxicity of Boric Acid (CAS No. 10043-35-3) in Sprague-Dawley CD® Rats Exposed on Gestation Days 6-15. Volume II
  • NTIS No. PB95-154647
    Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 6-15
  • F Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 0, .4, .5, .6, .8% *