National Toxicology Program

CASRN: 80-05-7

Formula: C15-H16-O2

Synonyms/Common Names:

• 4,4'-(1-METHYLETHYLIDENE)BISPHENOL

Known Uses:

INTERMEDIATE FOR RESINS, FLAME RETARDANTS, & RUBBER CHEMICALS, FUNGICIDE (HSDB 1990)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C50635) Completed 
  • NTIS No. PB82-184060  (Peer Review 10/15/1980)
    Citation: Carcinogenesis Bioassay of Bisphenol A (CAS No. 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C50635) Completed 
  • NTIS No. PB82-184060  (Peer Review 10/15/1980)
    Citation: Carcinogenesis Bioassay of Bisphenol A (CAS No. 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,250,4000, M: 0,5000,25000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C50635) Report Complete 
  • TR-215 (NTIS No. PB82-184060)  (Peer Review 10/15/1980)
    Carcinogenesis Bioassay of Bisphenol A (CAS No. 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Equivocal 
  • Male Mice Equivocal 
  • Female Mice Negative 
  • Dose: R: 0,1000,2000, FM: 0,5000,10000, MM: 0,1000,5000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (070061) Completed 
  • Mice
  • Chromosome Aberation  Positive (Nonstandard Protocol) 
• In Vitro Cytogenetics (CA/SCE)  (791721) Completed 
  • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (839656) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (831513) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Negative 
• Micronucleus  (A24930) Completed 
  • Rats: F344
  • Male Negative 
• Salmonella  (121422) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (441712) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (680342) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Sister Chromatid Exchanges  (070061) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

• 120 D MINIMUM Continuous Breeding (Subcutaneous Injection)  (RACB82081) Completed 
  • NTIS No. PB84-155308
    Citation: Final Report - Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered via Subcutaneous Silastic Implants
  • M/F Mice: Swiss
  • Dose: 0,6.25,12.5,25,50,100 MG; 0,25,50,100 MG/KG; N/A; N/A
• 120 D MINIMUM Continuous Breeding (Dosed-Feed)  (RACB84080) Completed 
  • NTIS No. PB86-103207
    Citation: Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered In the Feed
  • M/F Mice: Swiss
  • Dose: 0,.312,.625,1.25,2.5,5.0%; 0,.25,.5,1%; 0,1%; 0,.25,.5,1.0%;
• GD 6-15 Conventional Teratology (Gavage)  (TER85051) Completed 
  • NTIS No. PB85-205110
    Citation: Final Report - Teratologic Evaluation of Bisphenol A Administered to CD(R) Rats on Gestational Days 6 Through 15
  • F Rats: Sprague Dawley
  • Rats Maternal Negative 
  • Rats Fetal Negative 
  • Dose: 160, 320, 640, 1280 MG/KG/DY
• GD 6-15 Conventional Teratology (Gavage)  (TER85052) Completed 
  • NTIS No. PB85-205102
    Citation: Final Report - Teratologic Evaluation of Bisphenol A Administered to CD-1 Mice on Gestational Days 6 Through 15
  • F Mice: Swiss
  • Mice Maternal Positive 
  • Mice Fetal Positive 
  • Dose: 500, 750, 1000, 1250 MG/KG/DAY