National Toxicology Program

CASRN: 82-68-8

Formula: C6-CL5-N-O2

Synonyms/Common Names:

• BATRILEX

Known Uses:

FUNGICIDE, SOIL FUMIGANT AND SEED TREATMENT

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00419A) Completed 
  • NTIS No. PB281732  (Peer Review 01/18/1978)
    Citation: Bioassay of Pentachloronitrobenzene for Possible Carcinogenicity (CAS No. 82-68-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00419A) Completed 
  • NTIS No. PB281732  (Peer Review 01/18/1978)
    Citation: Bioassay of Pentachloronitrobenzene for Possible Carcinogenicity (CAS No. 82-68-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: 0,2150,46400 PPM/5 PER GROUP
• 13-Week (Dosed-Feed)  (C00419B) Completed 
  • NTIS No. PB87-208633  (Peer Review 03/26/1986)
    Citation: Toxicology and Carcinogenesis Studies of Pentachloronitrobenzene (CAS No. 82-68-8) in B6C3F1 Mice (Feed Studies)
  • Mice: B6C3F1
  • Dose: MM: 0,.125,2.00, FM: 0,.25,4.00 %/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00419A) Report Complete 
  • TR-061 (NTIS No. PB281732)  (Peer Review 01/18/1978)
    Bioassay of Pentachloronitrobenzene for Possible Carcinogenicity (CAS No. 82-68-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,5417,10064 (AVG), FR: 0, 7875, 14635 (AVG), MM: 0, 2606, 5213 (AVG), FM: 0, 4043, 8187 (AVG) PPM/50 PER GROUP
• 2-YEAR (Dosed-Feed)  (C00419B) Report Complete 
  • TR-325 (NTIS No. PB87-208633)  (Peer Review 03/26/1986)
    Toxicology and Carcinogenesis Studies of Pentachloronitrobenzene (CAS No. 82-68-8) in B6C3F1 Mice (Feed Studies)
  • Mice: B6C3F1
  • Carcinogenesis Results
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: 0,2500,5000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (027750) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (114657) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (303135) Completed 
  •  Negative 
• Salmonella  (251113) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative