National Toxicology Program

CASRN: 115-28-6

Formula: C9-H4-CL6-O4

Synonyms/Common Names:

• 1,4,5,6,7,7-HEXACHLOROBICYCLO(2.2.1)HEPT-5-ENE-2,3-DICARBONYLIC ACID (9CI)

Known Uses:

FLAME RETARDANT, INTERMEDIATE FOR PLASTICIZERS, HARDENING AGENT (HSDB 1990)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C55072) Completed 
  • NTIS No. PB87-206835  (Peer Review 08/14/1985)
    Citation: Toxicology and Carcinogenesis Studies of Chlorendic Acid (CAS No. 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C55072) Completed 
  • NTIS No. PB87-206835  (Peer Review 08/14/1985)
    Citation: Toxicology and Carcinogenesis Studies of Chlorendic Acid (CAS No. 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,620,10000, M: 0,1250,20000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C55072) Report Complete 
  • TR-304 (NTIS No. PB87-206835)  (Peer Review 08/14/1985)
    Toxicology and Carcinogenesis Studies of Chlorendic Acid (CAS No. 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice No Evidence 
  • Dose: 0,620,1250 PPM/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Gavage)  (S0074) Completed 
  • Citation: GM DECAD, MT FIELDS. Disposition and Excretion of Chlorendic Acid in Fischer 344 Rats. J TOX & ENV HLTH 9:911-920, 1982
  • M Rats; M Rats
  • Dose: PO: 3 MG/KG IV: 3 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (179071) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Inconclusive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (960855) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (197818) Completed 
  • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
  •  Positive 
• Salmonella  (995372) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative