National Toxicology Program

CASRN: 1825-21-4

Formula: C7-H3-CL5-O

Synonyms/Common Names:

• PENTACHLOROMETHOXYBENZENE (9CI)

Known Uses:

DEGRADATION PRODUCT OF OTHER CHEMICALS SUCH AS PENTACHLOROPHENOL AND PENTACHLORONITROBENZENE

Short-Term Toxicity

• 2-WEEK (Gavage)  (C56520) Completed 
  • NTIS No. PB94-104536  (Peer Review 11/21/1991)
    Citation: Toxicology and Carcinogenesis Studies of Pentachloroanisole (CAS No. 1825-21-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 100, 125, 150, 175, OR 200 MG/KG M: 0, 100, 175, 250, 325, OR 400 MG/KG
• 13-WEEK (Gavage)  (C56520) Completed 
  • NTIS No. PB94-104536  (Peer Review 11/21/1991)
    Citation: Toxicology and Carcinogenesis Studies of Pentachloroanisole (CAS No. 1825-21-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 40, 80, 120, 140, OR 180 MG/KG; 10/SEX/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C56520) Report Complete 
  • TR-414 (NTIS No. PB94-104536)  (Peer Review 11/21/1991)
    Toxicology and Carcinogenesis Studies of Pentachloroanisole (CAS No. 1825-21-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice No Evidence 
  • Dose: MR: 0, 10, 20, OR 40 FR&M: 0, 20, OR 40 MG/KG

Special Studies

• Toxicokinetic Study (Intravenous)  (S0361) Completed 
  • Citation: YUAN, J.H., GOEHL, T.J., MURRILL, E., MOORE, R., CLARK, J., HONG, L. & IRWIN, R.: TOXICOKINETICS OF PENTACHLOROANISOLE IN F344 RATS & B6C3F1 MICE, XENOBIOTICA, 23(4):427-438, 1993.
  • M/F Rats: F344/N; M/F Mice: B6C3F1

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (259382) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (644226) Completed 
  • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
  •  Positive 
• Salmonella  (596505) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive 

Organ Systems Toxicity

• GD 6-15 Conventional Teratology (Oral)  (T0120) Completed 
  • F Mice: Swiss
  • Dose: 0, 40, 80, 100, 160 MG/KG/DAY