Testing Status of Agents at NTP
8-Methoxypsoralen
CASRN: 298-81-7
Formula: C12-H8-O4
Synonyms/Common Names:
- 9-METHOXY-7H-FURO(3,2-G)(1)(BENZOPYRAN-7-ONE) (9CI)
- 8-MOP
Known Uses:
USED IN PUVA THERAPY FOR TREATMENT OF PSORIASIS & VITILIGO, IN TANNING PREP'NS (PRIMARILY PROD. IN EUROPE)
Short-Term Toxicity
- 14-Day (Gavage)
(C55903) Completed
- NTIS No. PB90-110164
(Peer Review 04/18/1988)
Citation: Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies) - Rats: F344/N
- NTIS No. PB90-110164
(Peer Review 04/18/1988)
- 13-Week (Gavage)
(C55903) Completed
- NTIS No. PB90-110164
(Peer Review 04/18/1988)
Citation: Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies) - Rats: F344/N
- Dose: 0,25,400 MG/KG/10 PER GROUP
- NTIS No. PB90-110164
(Peer Review 04/18/1988)
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C55903) Report Complete
- TR-359 (NTIS No. PB90-110164)
(Peer Review 04/18/1988)
Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats No Evidence
- Dose: R: 0, 37.5, 75 MG/KG/50 PER GROUP
- TR-359 (NTIS No. PB90-110164)
(Peer Review 04/18/1988)
Genetic Toxicology
- Chromosome Aberrations
(501444) Completed
- Mice
- Chromosome Aberation Positive
- In Vitro Cytogenetics (CA/SCE)
(421568) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Micronucleus
(158726) Completed
- Mice: B6C3F1
- Male Equivocal
- Salmonella
(773087) Completed
- Positive
Organ Systems Toxicity
- GD 6 THROUGH 9 Conventional Teratology (Gavage)
(TER91016) Completed
- NTIS No. PB94-181731
Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in New Zealand White Rabbits - NTIS No. PB94-191749
Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in New Zealand White Rabbits - F Rabbit: New Zealand White
- Rabbits Maternal Positive
- Rabbits Fetal Negative
- Dose: 0, 40, 80, 105 MG/KG
- NTIS No. PB94-181731
- GD 6-16 Conventional Teratology (Gavage)
(TER91017) Completed
- NTIS No. PB92-219666
Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in Sprague-Dawley (CD) Rats - Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: 0, 20, 80, 120, 160 MG/KG/DAY
- NTIS No. PB92-219666
- GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)
(TRP90007) Completed
- F Rats: Sprague Dawley
- Dose: 0, 20, 100, 200, 400, 600 MG/KG
- GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)
(TRP90008) Completed
- F Rabbit: New Zealand White
- Dose: 0, 10, 50, 80, 160 MG/KG
- GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)
(TRP91017) Completed
- F Rabbit: New Zealand White
- Dose: 0, 10, 50, 80, 105 MG/KG
Web page last updated on January 22, 2009