Testing Status of Agents at NTP
Ethylene oxide
CASRN: 75-21-8
Formula: C2-H4-O
Synonyms/Common Names:
- OXIRANE (9CI)
Known Uses:
ACCELERATES RIPENING IN FRUIT AND MATURING OF TOBACCO LEAVES. FUNGISTAT. ROCKET PROPELLANT. FUMIGANT FOR FOODSTUFFS AND TEXTILES. ORGANIC SYNTHESIS. STERILIZE SURGICAL INSTRUMENTS. CHEMICAL INTERMEDIATE. (TDB)
Short-Term Toxicity
- 14-Day (Inhalation)
(C50088) Completed
- NTIS No. PB88-169859
(Peer Review 08/19/1986)
Citation: Toxicology and Carcinogenesis Studies of Ethylene Oxide (CAS No. 75-21-8) in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- NTIS No. PB88-169859
(Peer Review 08/19/1986)
- 13-Week (Inhalation)
(C50088) Completed
- NTIS No. PB88-169859
(Peer Review 08/19/1986)
Citation: Toxicology and Carcinogenesis Studies of Ethylene Oxide (CAS No. 75-21-8) in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- Dose: 0,50,100,200,400,600 PPM/10 PER GROUP
- NTIS No. PB88-169859
(Peer Review 08/19/1986)
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C50088) Report Complete
- TR-326 (NTIS No. PB88-169859)
(Peer Review 08/19/1986)
Toxicology and Carcinogenesis Studies of Ethylene Oxide (CAS No. 75-21-8) in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: 0,50,100 PPM/50 PER GROUP
- TR-326 (NTIS No. PB88-169859)
(Peer Review 08/19/1986)
Organ Systems Toxicity
- Biochemical Specific Locus
(BSLM38) Completed
- Citation: Lewis, S.E., Barnett, L.B., Felton, C., Johnson, F.M., Skow, L.C., Cacheiro, N., and Shelby, M.D. Dominant visible and electrophoretically expressed mutations induced in male mice exposed to ethylene oxide by inhalation. Environ. Mutagen. 8:867-872 (1986).
- M Mice: DBA/2J
- Mice Male Positive
- Dominant Lethal (Female)
(DLF023) Completed
- Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990).
- F Mice: C3H X C57BL
- Mice Female Positive
- Dominant Lethal (Male)
(DLM022) Completed
- Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987).
- M Mice: C3H X 101
- Mice Male Positive
- Heritable Translocation Test
(HTM32) Completed
- Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990).
- M Mice: C3H X 101
- Mice Male Positive
- Morphological Specific Locus
(MSLM42) Completed
- Citation: Russell, L.B., Cummings, R.B., and Hunsicker, P.R. Specific-Locus mutation rates in the mouse following inhalation of ethylene oxide and application of the results estimation of human genetic risk. Mutation Res. 129:381-388 (1984).
- M Mice: 101 X C3H
- Mice Male Negative
- Preimplantation Zygote Effects
(PZEF48) Completed
- Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987).
- F Mice: C3H X C57BL
- Mice Female Positive
- 5 CONS D Continuous Breeding (Inhalation)
(T0024C) Completed
- M Mice: C3H
- Dose: 100 PPM 7HR/DY FOR 5
- GD 4-6,6-8,8-10,10-12 Conventional Teratology (Intravenous)
(T0024A) Completed
- NTIS No. PB84-219294
Citation: Teratologic Evaluation of Ethylene Oxide - F Mice: Swiss
- Dose: 75, 150 MG/KG/DAY
- NTIS No. PB84-219294
- GD 7-16, GD 1-16, OR 3 WK BEFORE BREEDING PLUS GD 1-16. Conventional Teratology (Inhalation)
(T0024D) Completed
- NTIS No. PB83-258038
Citation: Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate - F Rats: Sprague Dawley
- Dose: 150 PPM 7 HR/D
- NTIS No. PB83-258038
- GD 7-19 OR GD 1-19 Conventional Teratology (Inhalation)
(T0024E) Completed
- NTIS No. PB83-258038
Citation: Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate - F Rabbit: New Zealand White
- Dose: 150 PPM 7HR/D
- NTIS No. PB83-258038
- GD 6-14 AND GD 6-9 Conventional Teratology (Intravenous)
(TER82078) Completed
- NTIS No. PB83-242016
Citation: Teratologic Evaluation of Ethylene Oxide in New Zealand White Rabbits - F Rabbit: New Zealand White
- Rabbits Maternal Positive
- Rabbits Fetal Positive
- Dose: PART A: GD 6-14, WATER VEHICLE AT 0, 9, 18, & 36 MG/KG. PART B: GD 6-9, 5% DEXTROSE VEHICLE AT 0, 18, & 36 MG/KG.
- NTIS No. PB83-242016
- Total Reproductive Capacity
(TRC98017) Completed
- Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns ofFemale Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
- F Mice
- Mice Female Positive
Web page last updated on January 22, 2009