National Toxicology Program

CASRN: 75-00-3

Formula: C2-H5-CL

Synonyms/Common Names:

• ETHYL CHLORIDE

Known Uses:

THIS COMPOUND IS USED IN THE MANUFACTURE OF TETRAETHYL LEAD, ETHYL CELLULOSE, SULFANOL AND TRIONAL; AS AN ANESTHETIC; IN ORGANIC SYNTHESIS; AS AN ALKYLATING AGENT; IN REFRIGERATION; AS AN ANALYTICAL REAGENT; AS A SOLVENT FOR PHOSPHOROUS , SULFUR, FATS, OILS, RESINS AND WAXES; IN INSECTICIDES; AND AS AN ETHYLATING AGENT IN THE MANUFACTURE OF DYES AND DRUGS (RADIAN H&S, 1991)

Short-Term Toxicity

• 14-Day (Inhalation)  (C06224) Completed 
  • NTIS No. PB90-225053  (Peer Review 10/03/1988)
    Citation: Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CAS No. 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Inhalation)  (C06224) Completed 
  • NTIS No. PB90-225053  (Peer Review 10/03/1988)
    Citation: Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CAS No. 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,2500,19000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C06224) Report Complete 
  • TR-346 (NTIS No. PB90-225053)  (Peer Review 10/03/1988)
    Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CAS No. 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Inadequate Study 
  • Female Mice Clear Evidence 
  • Dose: R&M: 0, 15000 PPM/50 PER GROUP

Genetic Toxicology

• Micronucleus  (A92751) Completed 
  • Mice: B6C3F1
  • Male Not Tested 
• Salmonella  (306504) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Positive