National Toxicology Program

CASRN: 1330-20-7

Formula: C8 H10

Synonyms/Common Names:

• DIMETHYLBENZENE (9CI)

Known Uses:

SOLVENT, COMPONENT OF GASOLINE, PROTECTIVE COATINGS, IN MANUF. OF DYES, PHARMACEUTICALS, PERFUMES, PESTICIDES,PAINTS, ADHESIVES, INDIRECT FOOD ADDITIVE FOR USE AS COMPONENT OF ADHESIVES (HSDB 1990)

Nomination Background

Short-Term Toxicity

• 14-Day (Gavage)  (C55232) Completed 
  • NTIS No. PB87-189684  (Peer Review 03/26/1986)
    Citation: Toxicology and Carcinogenesis Studies of Xylenes (Mixed) (60%m-Xylene, 14%p-Xylene, 9%o-Xylene, and 17% Ethylbenzene)(CAS No. 1330-20-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C55232) Completed 
  • NTIS No. PB87-189684  (Peer Review 03/26/1986)
    Citation: Toxicology and Carcinogenesis Studies of Xylenes (Mixed) (60%m-Xylene, 14%p-Xylene, 9%o-Xylene, and 17% Ethylbenzene)(CAS No. 1330-20-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,6.25,1000, M: 0,125,2000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C55232) Report Complete 
  • TR-327 (NTIS No. PB87-189684)  (Peer Review 03/26/1986)
    Toxicology and Carcinogenesis Studies of Xylenes (Mixed) (60%m-Xylene, 14%p-Xylene, 9%o-Xylene, and 17% Ethylbenzene)(CAS No. 1330-20-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,250,500, M: 0,500,1000 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (744839) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (196823) Completed 
  • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
  •  Positive 
• Salmonella  (719358) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 

Organ Systems Toxicity

• GD 6-15 Conventional Teratology  (T0118) Completed 
  • F Mice: Swiss
  • Dose: 0, 0.6, 1.2, 2.4, 3.0, 3.6, 4.8 ML/KG/DAY