Summaries & Associations of Study Results
Levels from TR-525 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF)
Target Organs and Levels of Evidence
NTP Technical Report Number 525
Produced from Chemtrack Database 02/07/06
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TEF EVALUATION (PECDF (PENTACHLORODIBENZOFURAN)) 57117-31-4 |
02/17/04 | ONE OF 5 DIOXIN-LIKE COMPOUNDS PLUS 2 MIXTURES BEING TESTED TO DETERMINE IF THE TOXIC EQUIVALENCY FACTORS (TEFS) FOR THESE CHEMICALS WOULD BE PREDICTIVE OF RODENT CARCINOGENICITY. | Gavage FEMALE RATS ONLY: PeCDF -- 0, 6, 20, 44, 92, OR 200 NG/KG; 100/DOSE | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| FR: SOME EVIDENCE | LIVER: ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50 | |||
| ORAL MUCOSA: GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 2/53 1/53 0/53 1/53 3/53 3/50 | ||||
| MAY HAVE BEEN RELATED: | LUNG: CYSTIC KERATINIZING EPITHELIOMA (MULTIPLE) 0/53 0/53 0/53 0/53 0/53 1/52 0/50 | |||
| PANCREAS ACINAR CELL: ADENOMA OR CARCINOMA 0/53 0/53 0/53 0/52 2/52 0/52 2/49 | ||||
| UTERUS: CARCINOMA 1/53 1/53 0/53 1/53 5/53 2/53 1/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; OVAL CELL HYPERPLASIA; DIFFUSE FATTY CHANGE; PIGMENTATION; NODULAR HYPERPLASIA; EOSINOPHILIC FOCUS; NECROSIS; BILE DUCT HYPERPLASIA; BILE DUCT FIBROSIS; TOXIC HEPATOPATHY; CHOLANGIOFIBROSIS | |||
| ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA | ||||
| UTERUS: ENDOMETRIAL CYSTIC HYPERPLASIA; CHRONIC ACTIVE INFLAMMATION; SQUAMOUS METAPLASIA | ||||
| LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA | ||||
| PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION | ||||
| THYROID GLAND: FOLLICULAR CELL HYPERTROPHY | ||||
| THYMUS: ATROPHY; SEVERITY OF ATROPHY | ||||
| ADRENAL CORTEX: CYSTIC DEGENERATION | ||||
| KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY | ||||
| HEART: CARDIOMYOPATHY | ||||
| FORESTOMACH: SQUAMOUS HYPERPLASIA | ||||
Web page last updated on February 10, 2006
