Summaries & Associations of Study Results
Levels from TR-521 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
Target Organs and Levels of Evidence
NTP Technical Report Number 521
Produced from Chemtrack Database 02/07/06
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TEF EVALUATION (TCDD) 1746-01-6 |
02/17/04 | ONE OF 5 DIOXIN-LIKE COMPOUNDS PLUS 2 MIXTURES BEING TESTED TO DETERMINE IF THE TOXIC EQUIVALENCY FACTORS (TEFS) FOR THESE CHEMICALS WOULD BE PREDICTIVE OF RODENT CARCINOGENICITY. | Gavage FEMALE RATS ONLY: TCDD -- 0, 3, 10, 22, 46, OR 100 NG/KG; 100/DOSE | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| FR: CLEAR EVIDENCE | LIVER: ADENOMA 0/53 0/54 0/53 0/53 1/53 13/53 2/50 OR CHOLANGIOCARCINOMA 0/53 0/54 0/53 1/53 4/53 25/53 2/50 | |||
| LUNG: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/54 0/53 0/52 0/53 9/52 0/50 | ||||
| ORAL MUCOSA: GINGIVAL SQAMOUS CELL CARCINOMA 1/53 2/54 1/53 0/53 4/53 10/53 5/50 | ||||
| UTERUS: SQUAMOUS CELL CARCINOMA 0/53 0/54 0/53 0/53 5/53 0/53 2/50 | ||||
| MAY HAVE BEEN RELATED: | PANCREAS ACINAR CELL: ADENOMA OR CARCINOMA 0/51 0/54 0/52 0/53 0/52 3/51 1/49 | |||
| LIVER: HEPATOCHOLANGIOMA 0/53 0/54 0/53 0/53 0/53 2/53 0/50 OR CHOLANGIOMA 0/53 0/54 0/53 0/53 0/53 0/53 1/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; EOSINOPHILIC FOCUS; INFLAMMATION; PIGMENTATION; DIFFUSE FATTY CHANGE; NECROSIS; OVAL CELL HYPERPLASIA; BILE DUCT HYPERPLASIA; BILE DUCT CYST; NODULAR HYPERPLASIA; PORTAL FIBROSIS; TOXIC HEPATOPATHY; CHOLANGIOFIBROSIS | |||
| LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR | ||||
| ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA | ||||
| PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; CHRONIC ACTIVE INFLAMMATION; ACINAR ATROPHY; ARTERIAL CHRONIC ACTIVE INFLAMMATION | ||||
| THYMUS: ATROPHY; SEVERITY OF ATROPHY | ||||
| ADRENAL CORTEX: ATROPHY; HYPERPLASIA | ||||
| HEART: CARDIOMYOPATHY | ||||
| CLITORAL GLAND: CYSTIC DUCT | ||||
| KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY | ||||
| FORESTOMACH: SQUAMOUS HYPERPLASIA | ||||
| THYROID GLAND: FOLLICULAR CELL HYPERTROPHY | ||||
Web page last updated on February 10, 2006
