Summaries & Associations of Study Results
TR-508 Riddelliine
Target Organs and Levels of Evidence
NTP Technical Report Number 508
Produced from Chemtrack Database 12/14/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| RIDDELLIINE 23246-96-0 |
10/18/01 | NATURALLY OCCURRING PHARMACEUTICAL AGENT | Gavage MR: 0 OR 1.0 MG/KG; 50/DOSE FR: 0, 0.01, 0.033, 0.1, 0.33, OR 1.0 MG/KG; 62/DOSE MM: 0, 0.1, 0.3, 1.0, OR 3.0 MG/KG; 50/DOSE FM: 0 OR 3.0 MG/KG; 50/DOSE | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | LIVER: HEMANGIOSARCOMA 0/50 43/50; ADENOMA 0/50 4/50 | |||
| MONONUCLEAR CELL LEUKEMIA (ALL ORGANS): 2/50 9/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: REGENERATIVE HEPATOCYTE HYPERPLASIA; HEPATOCYTE CYTOMEGALY; FOCAL NECROSIS; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; HEMORRHAGE | |||
| KIDNEY: TUBULE NECROSIS | ||||
| FR: CLEAR EVIDENCE | LIVER: HEMANGIOSARCOMA 0/50 0/50 0/50 0/50 3/50 38/50; ADENOMA 1/50 0/50 0/50 0/50 1/50 7/50 | |||
| MONONUCLEAR CELL LEUKEMIA (ALL ORGANS): 12/50 8/50 13/50 18/50 18/50 14/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: REGENERATIVE HEPATOCYTE HYPERPLASIA; HEPATOCYTE CYTOMEGALY; FOCAL NECROSIS; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; CLEAR CELL FOCUS; BILE DUCT HYPERPLASIA; HEMORRHAGE | |||
| KIDNEY: TUBULE NECROSIS; TRANSITIONAL EPITHELIAL HYPERPLASIA | ||||
| MM: CLEAR EVIDENCE | LIVER: HEMANGIOSARCOMA 2/50 1/50 0/50 2/50 31/50 | |||
| OTHER :CONSIDERATIONS: | LIVER: ADENOMA 16/50 18/50 14/50 5/50 0/50 CARCINOMA 23/50 21/50 19/50 20/50 3/50 COMBINED 36/50 39/50 33/50 23/50 3/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: HEPATOCYTE CYTOMEGALY; HEPATOCYTE KARYOMEGALY; CENTRILOBULAR HEPATOCYTE NECROSIS; FOCAL HEMORRHAGE; INCREASED SEVERITY OF FOCAL HEPATOCYTE NECROSIS | |||
| KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; GLOMERULOSCLEROSIS; TUBULE KARYOMEGALY; TUBULE DILATATION | ||||
| FM: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 COMBINED 2/50 13/50 | |||
| OTHER :CONSIDERATIONS: | LIVER: ADENOMA 9/59 0/50 OR CARCINOMA 8/49 0/50 COMBINED 16/49 0/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: HEPATOCYTE CYTOMEGALY; HEPATOCYTE KARYOMEGALY; CENTRILOBULAR HEPATOCYTE NECROSIS; FOCAL HEMORRHAGE; INCREASED SEVERITY OF FOCAL HEPATOCYTE NECROSIS | |||
| KIDNEY: NEPHROPATHY; INCREASED SEVERITY OF NEPHROPATHY; GLOMERULOSCLEROSIS; TUBULE HYALINE DROPLET ACCUMULATION; TUBULE PIGMENTATION | ||||
| LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA | ||||
| ARTERIES (CHRONIC ARTERIAL INFLAMMATION INCLUDES FOCAL): SMALL INTESTINE (DUODENUM); LARGE INTESTINE (CECUM); KIDNEY; MESENTERY; OVARY; SPLEEN; UTERUS | ||||
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