Summaries & Associations of Study Results
TR-484 2-Butoxyethanol (Ethylene Glycol Monobutyl Ether)
Target Organs and Levels of Evidence
NTP Technical Report Number 484
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 2-BUTOXYETHANOL (ETHYLENE GLYCOL MONOBUTYL ETHER) 111-76-2 |
10/30/98 | SOLVENT FOR MINERAL OILS, IN SPRAY LACQUERS, VARNISH REMOVERS, AND INKS; IN DEGREASERS IN INDUSTRIAL AND HOUSEHOLD CLEANERS ` | Inhalation R: 0, 31, 62.5, OR 125 PPM M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION | |||
| LIVER: KUPFFER CELL PIGMENTATION | ||||
| FR: EQUIVOCAL EVIDENCE | ||||
| MAY HAVE BEEN RELATED: | ADRENAL GLAND MEDULLA: BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 3/50 4/50 1/49 8/49 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION | |||
| LIVER: KUPFFER CELL PIGMENTATION | ||||
| MM: SOME EVIDENCE | VASCULAR SYSTEM (LIVER): HEMANGIOSARCOMA 0/50 1/50 2/49 4/49 | |||
| MAY HAVE BEEN RELATED: | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 1/50 1/50 2/49 2/49 | |||
| LIVER: HEPATOCELLULAR CARCINOMA 10/50 11/50 16/49 21/49 | ||||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: ULCER; EPITHELIAL HYPERPLASIA | |||
| SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; HEMOSIDERIN PIGMENTATION | ||||
| BONE MARROW: HYPERPLASIA | ||||
| LIVER: KUPFFER CELL PIGMENTATION | ||||
| FM: SOME EVIDENCE | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 5/50 COMBINED 0/50 1/50 2/50 6/50 | |||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: ULCER; EPITHELIAL HYPERPLASIA | |||
| SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; HEMOSIDERIN PIGMENTATION | ||||
| NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION; RESPIRATORY EPITHELIUM; HYALINE DEGENERATION | ||||
| LIVER: KUPFFER CELL PIGMENTATION | ||||
Web page last updated on February 10, 2006
