Summaries & Associations of Study Results
TR-470 Pyridine
Target Organs and Levels of Evidence
NTP Technical Report Number 470
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| PYRIDINE 110-86-1 |
12/10/97 | SOLVENT, ORGANIC SYNTHESIS, FLAVORING INGREDIENT, MANUFACTURE OF FUNGICIDES, PHARMACEUTICALS, DYESTUFF, EXPLOSIVES, MFR OF VITAMINS, SULFA DRUGS, INTR IN MANUF OF DIQUAT & PARAQUAT, WATERPROOFING TEXTILES (HSDB 1990) | Dosed-Water R: 0, 100, 200, OR 400 PPM MM: 0, 250, 500, OR 1000 PPM FM: 125, 250, OR 500 PPM MWR: 0, 100, 200, OR 400 PPM (50/SEX/GROUP) | T.S.I. Mason Laboratories, Inc. |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | KIDNEY TUBULAR CELL: (SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49; (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: CENTRILOBULAR CYTOMEGALY; CYTOPLASMIC VACUOLIZATION; CENTRILOBULAR DEGENERATION OR NECROSIS; PIGMENTATION | |||
| FR: EQUIVOCAL EVIDENCE | ||||
| MAY HAVE BEEN RELATED: | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 12/50 16/50 22/50 23/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: CENTRILOBULAR CYTOMEGALY; CYTOPLASMIC VACUOLIZATION; CENTRILOBULAR DEGENERATION OR NECROSIS; PIGMENTATION | |||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 29/50 40/50 34/49 39/50, CARCINOMA 15/50 35/50 41/49 40/50, HEPATOBLASTOMA 2/50 18/50 22/49 15/50 | |||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 37/49 39/50 43/50 34/50, CARCINOMA 13/49 23/50 33/50 41/50, HEPATOBLASTOMA 1/49 2/50 9/50 16/50 | |||
| PYRIDINE 110-86-1 |
12/10/97 | SOLVENT, ORGANIC SYNTHESIS, FLAVORING INGREDIENT, MANUFACTURE OF FUNGICIDES, PHARMACEUTICALS, DYESTUFF, EXPLOSIVES, MFR OF VITAMINS, SULFA DRUGS, INTR IN MANUF OF DIQUAT & PARAQUAT, WATERPROOFING TEXTILES (HSDB 1990) | Dosed-Water | T.S.I. Mason Laboratories, Inc. |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: EQUIVOCAL EVIDENCE | TESTIS: INTERSTITIAL CELL ADEMONA 5/50 6/49 4/49 12/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: CENTRILOBULAR DEGENERATION AND NECROSIS, FIBROSIS, PIGMENTATION | |||
| PARATHYROID GLAND: HYPERPLASIA | ||||
Web page last updated on February 10, 2006
