Summaries & Associations of Study Results
TR-460 Feed Restriction Studies
Target Organs and Levels of Evidence
NTP Technical Report Number 460
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| FEED RESTRICTION STUDIES FEEDRESTRICT |
06/20/95 | FEED RESTRICTION STUDIES | VARIOUS | NA |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| NOTE: | THE EFFECTS OF DIET RESTRICTION ON THE SENSITIVITY OF THE BIOASSAY TOWARD CHEMICAL-INDUCED CHRONIC TOXICITY AND CARCINOGENICITY IN RATS AND MICE WERE EVALUATED FOR BUTYL BENZYL PHTHALATE AND T-BUTYLHYDROQUINONE IN FEED, SALICYLAZOSULFAPYRIDINE IN CORN OIL BY GAVAGE, AND SCOPOLAMINE HYDROBROMIDE TRIHYDRATE IN DISTILLED WATER BY GAVAGE. DIET RESTRICTION INCREASED SURVIVAL RATES AND | |||
| DECREASED THE INCIDENCES OF NEOPLASMS AND NONNEOPLASTIC LESIONS AT A VARIETY OF SITES | ||||
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