Summaries & Associations of Study Results
TR-453 Nickel Subsulfide
Target Organs and Levels of Evidence
NTP Technical Report Number 453
Produced from Chemtrack Database 09/19/01
CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
---|---|---|---|---|
NICKEL SUBSULFIDE 12035-72-2 |
11/29/94 | MAJOR COMPONENT IN NICKEL REFINERY FLUE DUST. NOT USED COMMERCIALLY IN U.S. (TDB) | Inhalation R: 0, 0.075, OR 0.15 M: 0, 0.6, OR 1.2 MG/M3; 50/GROUP | Lovelace Inhal Tox Res Inst (DOE) |
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
MR: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR ADENOMA OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 6/53 11/53 | |||
ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 13/53 30/52 38/53 OR MALIGNANT PHEOCHROMOCYTOMA 0/53 2/52 10/53 COMBINED 14/53 30/52 38/53 | ||||
NON-NEOPLASTIC LESIONS: | LUNG: CHRONIC ACTIVE INFLAMMATION; FOCAL ALVEOLAR EPITHELIAL HYPERPLASIA; MACROPHAGE HYPERPLASIA; FIBROSIS | |||
NASAL CAVITY: CHRONIC ACTIVE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY | ||||
FR: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 2/53 5/53 5/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53 OR SQUAMOUS CELL CARCINOMA 0/53 1/53 0/53 COMBINED 2/53 6/53 9/53 | |||
ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 2/53 7/53 36/53 | ||||
NON-NEOPLASTIC LESIONS: | LUNG: CHRONIC ACTIVE INFLAMMATION; FOCAL ALVEOLAR EPITHELIAL HYPERPLASIA; MACROPHAGE HYPERPLASIA; FIBROSIS | |||
NASAL CAVITY: CHRONIC ACTIVE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY | ||||
ADRENAL GLAND: (MEDULLA) HYPERPLASIA | ||||
MM: NO EVIDENCE | ||||
NON-NEOPLASTIC LESIONS: | LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; FIBROSIS | |||
NASAL CAVITY: ACUTE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY | ||||
FM: NO EVIDENCE | ||||
NON-NEOPLASTIC LESIONS: | LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; FIBROSIS | |||
NASAL CAVITY: ACUTE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY |
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