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Summaries & Associations of Study Results

TR-451 Nickel (II) Oxide

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Target Organs and Levels of Evidence
NTP Technical Report Number 451

Produced from Chemtrack Database 09/19/01

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
NICKEL (II) OXIDE
1313-99-1 		11/29/94 CHEMICAL INTERMEDIATE FOR STAINLESS AND ALLOY STEELS. CATALYSTS. ELECTRICAL DEVICES. THERMISTER MATERIAL. (TDB) Inhalation R: 0, .62, 1.25, OR 2.5 M: 0, 1.25, 2.5, OR 5.0 MG/M3; 50/GROUP Lovelace Inhal Tox Res Inst (DOE)
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: SOME EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/54 1/53 3/53 2/52 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/54 0/53 3/53 2/52 OR SQUAMOUS CELL CARCINOMA 1/54 0/53 0/53 0/52 COMBINED 1/54 1/53 6/53 4/52
ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 27/54 24/52 26/53 32/52 OR MALIGNANT PHEOCHROMOCYTOMA 0/54 0/52 1/53 6/52 COMBINED 27/54 24/52 27/53 35/52
NON-NEOPLASTIC LESIONS: LUNG: CHRONIC INFLAMMATION; PIGMENT
LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; PIGMENT
FR: SOME EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/53 0/53 1/53 4/54 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 0/53 5/53 1/54 COMBINED 1/53 0/53 6/53 5/54
ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 4/51 7/52 6/53 18/53
NON-NEOPLASTIC LESIONS: LUNG: CHRONIC INFLAMMATION; PIGMENT
LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; PIGMENT
ADRENAL GLAND: (MEDULLA) HYPERPLASIA
MM: NO EVIDENCE
NON-NEOPLASTIC LESIONS: LUNG: CHRONIC INFLAMMATION; PIGMENT
LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; PIGMENT
FM: EQUIVOCAL EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 2/64 4/66 10/63 3/64 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 4/64 11/66 4/63 5/64 COMBINED 6/64 15/66 12/63 8/64
NON-NEOPLASTIC LESIONS: LUNG: CHRONIC INFLAMMATION; PIGMENT
LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; PIGMENT

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