Study Results & Research Projects

Summaries & Associations of Study Results

TR-448 Isobutyl Nitrite

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Target Organs and Levels of Evidence
NTP Technical Report Number 448

Produced from Chemtrack Database 09/19/01

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
ISOBUTYL NITRITE
542-56-3 		11/29/94 INDUSTRIAL INTERMEDIATE IN CHEMICAL SYNTHESIS. (TDB) Inhalation R&M: 0, 37, 75, OR 150 PPM IIT Research Institute
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: CLEAR EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 3/46 12/46 13/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/46 2/46 1/46 6/46 COMBINED 1/46 5/46 13/46 15/46
OTHER :CONSIDERATIONS: HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 27/46 2/46 1/46 1/46
NON-NEOPLASTIC LESIONS: LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
FR: CLEAR EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 2/45 2/46 10/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/46 1/45 0/46 1/46 COMBINED 0/46 3/45 2/46 11/46
OTHER :CONSIDERATIONS: HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/46 1/45 0/46 1/46
NON-NEOPLASTIC LESIONS: LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
MM: SOME EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 12/50 13/49 17/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/49 4/53 COMBINED 8/50 16/50 16/49 19/53
MAY HAVE BEEN RELATED: THYROID GLAND FOLLICULAR CELL: ADENOMA 1/50 0/50 0/50 5/53
NON-NEOPLASTIC LESIONS: LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
SPLEEN: HEMOSIDERIN PIGMENTATION
FM: SOME EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 4/51 14/51 7/50 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/51 2/51 2/50 2/50 COMBINED 6/51 15/51 9/50 19/50
NON-NEOPLASTIC LESIONS: LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
NASAL CAVITY: SEROUS EXUDATE; OLFACTORY EPITHELIAL ATROPHY

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