Summaries & Associations of Study Results
TR-448 Isobutyl Nitrite
Target Organs and Levels of Evidence
NTP Technical Report Number 448
Produced from Chemtrack Database 09/19/01
CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
---|---|---|---|---|
ISOBUTYL NITRITE 542-56-3 |
11/29/94 | INDUSTRIAL INTERMEDIATE IN CHEMICAL SYNTHESIS. (TDB) | Inhalation R&M: 0, 37, 75, OR 150 PPM | IIT Research Institute |
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
MR: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 3/46 12/46 13/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/46 2/46 1/46 6/46 COMBINED 1/46 5/46 13/46 15/46 | |||
OTHER :CONSIDERATIONS: | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 27/46 2/46 1/46 1/46 | |||
NON-NEOPLASTIC LESIONS: | LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA | |||
FR: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 2/45 2/46 10/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/46 1/45 0/46 1/46 COMBINED 0/46 3/45 2/46 11/46 | |||
OTHER :CONSIDERATIONS: | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/46 1/45 0/46 1/46 | |||
NON-NEOPLASTIC LESIONS: | LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA | |||
MM: SOME EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 12/50 13/49 17/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/49 4/53 COMBINED 8/50 16/50 16/49 19/53 | |||
MAY HAVE BEEN RELATED: | THYROID GLAND FOLLICULAR CELL: ADENOMA 1/50 0/50 0/50 5/53 | |||
NON-NEOPLASTIC LESIONS: | LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA | |||
THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | ||||
SPLEEN: HEMOSIDERIN PIGMENTATION | ||||
FM: SOME EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 4/51 14/51 7/50 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/51 2/51 2/50 2/50 COMBINED 6/51 15/51 9/50 19/50 | |||
NON-NEOPLASTIC LESIONS: | LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA | |||
NASAL CAVITY: SEROUS EXUDATE; OLFACTORY EPITHELIAL ATROPHY |
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