Summaries & Associations of Study Results
TR-439 Methylphenidate Hydrochloride
Target Organs and Levels of Evidence
NTP Technical Report Number 439
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| METHYLPHENIDATE HYDROCHLORIDE 298-59-9 |
06/22/93 | CENTRAL STIMULANT | Dosed-Feed R: 0, 100, 500, OR 1000 PPM M: 0, 50, 250, OR 500 PPM; 50 PER GROUP | T.S.I. Mason Laboratories, Inc. |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| FR: NO EVIDENCE | ||||
| OTHER :CONSIDERATIONS: | MAMMARY GLAND: FIBROADENOMA 15/49 13/50 6/48 5/50 | |||
| MM: SOME EVIDENCE | LIVER: HEPATOCELLULAR ADENOMA 18/50 18/50 16/50 29/50 CARCINOMA 10/50 9/50 17/50 11/50 COMBINED 24/50 23/50 26/50 34/50; HEPATOBLASTOMA 0/50 1/50 1/50 5/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: EOSINOPHILIC FOCI | |||
| FM: SOME EVIDENCE | LIVER: HEPATOCELLULAR ADENOMA 6/49 10/48 10/49 28/50 CARCINOMA 5/49 3/48 2/49 6/50 COMBINED 9/49 11/48 11/49 30/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: EOSINOPHILIC FOCI | |||
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