Summaries & Associations of Study Results
TR-423 3,4-Dihydrocoumarin
Target Organs and Levels of Evidence
NTP Technical Report Number 423
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 3,4-DIHYDROCOUMARIN 119-84-6 |
06/23/92 | FRAGRANCE IN COSMETICS AND DETERGENTS. FLAVORING AGENT IN FOODS AND BEVERAGES. (TDB) | Gavage R: 0,150,300,600, M: 0,200,400,800 MG/KG/50 PER GROUP | American Biogenics Corp (Bioassay Systems) |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 0/50 1/48 0/47 2/50, STEP SECTIONS 1/50 0/48 3/47 5/50 | |||
| MAY HAVE BEEN RELATED: | KIDNEY TRANSITIONAL CELL: CARCINOMA 0/50 0/48 0/47 2/50 | |||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: ULCER; HYPERPLASIA; INFLAMMATION | |||
| PARATHYROID GLAND: HYPERPLASIA | ||||
| KIDNEY: TUBULAR CELL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY | ||||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | |||
| MM: NO EVIDENCE | ||||
| FM: SOME EVIDENCE | LIVER: ADENOMA 10/51 20/50 22/50 20/52 OR CARCINOMA 3/51 2/50 4/50 6/52 COMBINED 13/51 21/50 25/50 24/52 | |||
Web page last updated on February 10, 2006
