Summaries & Associations of Study Results
TR-420 Triamterene
Target Organs and Levels of Evidence
NTP Technical Report Number 420
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TRIAMTERENE 396-01-0 |
11/21/91 | DIURETIC AND NATRIURETIC AGENT. (TDB) | Dosed-Feed R: 0,150,300,600, M: 0,100,200,400 PPM RESTART MICE: 0,400 PPM/50 PER GROUP | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: EQUIVOCAL EVIDENCE | LIVER: ADENOMA 0/50 6/50 4/50 3/49 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: HYPERPLASIA; EOSINOPHILIC FOCI; MIXED CELL FOCI; INCREASED SEVERITY OF NEPHROPATHY | |||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: CLEAR CELL FOCI; MIXED CELL FOCI; INCREASED SEVERITY OF NEPHROPATHY | |||
| MM: SOME EVIDENCE | LIVER: (FIRST STUDY) ADENOMA 17/50 22/50 19/50 20/60 OR CARCINOMA 5/50 7/50 3/50 13/60 COMBINED 20/50 26/50 19/50 29/60; (SECOND STUDY) ADENOMA 21/50 36/50 OR CARCINOMA 9/50 11/50 COMBINED 25/50 38/50 | |||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: (FIRST STUDY) FOLLICULAR CELL HYPERPLASIA; (SECOND STUDY) FOLLICULAR CELL HYPERPLASIA | |||
| FM: SOME EVIDENCE | LIVER: (FIRST STUDY) ADENOMA 10/50 22/50 23/50 36/60 OR CARCINOMA 4/50 4/50 3/50 8/60 COMBINED 13/50 26/50 25/50 37/60; (SECOND STUDY) ADENOMA 7/50 28/51 OR CARCINOMA 5/50 11/51 COMBINED 10/50 31/51 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: (FIRST STUDY) BASOPHILIC FOCI, CLEAR CELL FOCI; (SECOND STUDY) BASOPHILIC FOCI, CLEAR CELL FOCI | |||
| THYROID GLAND: (FIRST STUDY) FOLLICULAR CELL HYPERPLASIA; (SECOND STUDY) FOLLICULAR CELL HYPERPLASIA | ||||
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