Summaries & Associations of Study Results
TR-407 C.I. Pigment Red 3
Target Organs and Levels of Evidence
NTP Technical Report Number 407
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| C.I. PIGMENT RED 3 2425-85-6 |
07/09/91 | USED IN MANUFACTURE OF PAINTS, INKS, PLASTICS, RUBBER. (TDB) | Dosed-Feed R: 0, 6000, 12500, 25000; M: 0, 12500, 25000, 50000 PPM (60 PER GROUP) | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50 | |||
| OTHER :CONSIDERATIONS: | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 22/50 6/50 2/50 1/50 | |||
| PREPUTIAL GLAND: ADENOMA 6/49 0/13 1/25 1/50 OR CARCIN0MA 1/49 0/13 0/25 0/50 COMBINED 7/49 0/13 1/25 1/50 | ||||
| MAY HAVE BEEN RELATED: | SKIN: SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50 | |||
| ZYMBAL GLAND: CARCINOMA 0/50 0/50 2/50 3/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: FOCAL CELLULAR ALTERATIONS | |||
| KIDNEY: NEPHROPATHY, CHRONIC | ||||
| FR: SOME EVIDENCE | LIVER: ADENOMA 0/50 0/50 1/50 10/50 | |||
| OTHER :CONSIDERATIONS: | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 10/50 1/50 0/50 2/50 | |||
| CLITORAL GLAND: ADENOMA 9/47 1/14 0/14 1/50 | ||||
| MAMMARY GLAND: FIBROADENOMA 23/50 16/50 20/49 12/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: FOCAL CELLULAR ALTERATIONS | |||
| KIDNEY: NEPHROPATHY, CHRONIC | ||||
| MM: SOME EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 0/50 0/50 0/50 6/50 | |||
| THYROID GLAND FOLLICULAR CELL: ADENOMA 0/50 0/49 1/50 5/50 | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: NEPHROPATHY, CHRONIC; RENAL TUBULE, EPITHELIUM, CYTOMEGALY. | |||
| THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | ||||
| FM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: NEPHROPATHY, CHRONIC | |||
| THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | ||||
Web page last updated on February 10, 2006
