Summaries & Associations of Study Results
R-404 5,5-Diphenylhydantoin (Phenytoin)
Target Organs and Levels of Evidence
NTP Technical Report Number 404
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 5,5-DIPHENYLHYDANTOIN (PHENYTOIN) 57-41-0 |
06/24/92 | DRUG; THERAPEUTIC AGENT USED AS ANTICONVULSANT, ANTIEPILEPTIC; ANTIARRHYTHMIC DRUG | Dosed-Feed R: 0,240,800,2400, MM: 0,30,100,300, FM: 0,60,200,600 PPM/50 PER GROUP | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: EQUIVOCAL EVIDENCE | LIVER: ADENOMA 0/50 1/50 4/50; CARCINOMA 0/50 1/50 0/50 | |||
| OTHER :CONSIDERATIONS: | LIVER: BASOPHILIC FOCUS 17/50 15/50 4/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: CENTRILOBULAR HYPERTROPHY | |||
| FR: NO EVIDENCE | ||||
| OTHER :CONSIDERATIONS: | LIVER: BASOPHILIC FOCUS 40/50 33/50 6/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: CENTRILOBULAR HYPERTROPHY | |||
| MM: NO EVIDENCE | ||||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 5/48 13/49 22/50, HEPATOBLASTOMA OR CARCINOMA 0/48 1/49 12/50, COMBINED 5/48 14/49 30/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: CENTRILOBULAR HYPERTROPHY | |||
Web page last updated on February 10, 2006
