Summaries & Associations of Study Results
TR-399 Titanocene Dichloride
Target Organs and Levels of Evidence
NTP Technical Report Number 399
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TITANOCENE DICHLORIDE 1271-19-8 |
11/19/90 | RESEARCH CHEMICAL. CATALYST. (TDB) | Gavage RATS ONLY:0,25,50 MG/KG/80 PER GROUP | T.S.I. Mason Laboratories, Inc. |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: EQUIVOCAL EVIDENCE | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/60 4/60 1/60; BENIGN BASOSQUAMOUS TUMOR 0/60 0/60 1/60; SQUAMOUS CELL CARCINOMA 0/60 1/60 0/60 | |||
| NON-NEOPLASTIC LESIONS: | GLANDULAR STOMACH: EROSIONS; INFLAMMATION; HYPERPLASIA; METAPLASIA; FIBROSIS; FAT PROLIFERATION | |||
| FORESTOMACH: ACANTHOSIS (EPITHELIAL HYPERPLASIA); HYPERKERATOSIS | ||||
| LIVER: GRANULOMATOUS INFLAMMATION | ||||
| VARIOUS ORGANS: PIGMENTATION | ||||
| LUNG: INFILTRATION, CELLULAR, HISTIOCYTIC; ACUTE INFLAMMATION; GRANULOMATOUS INFLAMMATION | ||||
| NASAL CAVITY: ACUTE INFLAMMATION | ||||
| FR: EQUIVOCAL EVIDENCE | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/60 1/60 2/60 | |||
| NON-NEOPLASTIC LESIONS: | GLANDULAR STOMACH: EROSIONS; INFLAMMATION; HYPERPLASIA; METAPLASIA; FIBROSIS; FAT PROLIFERATION | |||
| FORESTOMACH: ACANTHOSIS (EPITHELIAL HYPERPLASIA); HYPERKERATOSIS | ||||
| LIVER: GRANULOMATOUS INFLAMMATION | ||||
| VARIOUS ORGANS: PIGMENTATION | ||||
| LUNG: INFILTRATION, CELLULAR, HISTIOCYTIC; ACUTE INFLAMMATION; GRANULOMATOUS INFLAMMATION | ||||
| NASAL CAVITY: ACUTE INFLAMMATION | ||||
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