Study Results & Research Projects

Summaries & Associations of Study Results

TR-391 Tris(2-Chloroethyl) Phosphate

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http://ntp.niehs.nih.gov/go/9140

Target Organs and Levels of Evidence
NTP Technical Report Number 391

Produced from Chemtrack Database 09/19/01

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
TRIS(2-CHLOROETHYL) PHOSPHATE
115-96-8 		04/25/90 FLAME RETARDANT. PLASTICIZER. (TDB) Gavage R: 0,44,88; M: 0,175,350 MG/KG/60 PER GROUP Microbiological Associates
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: CLEAR EVIDENCE KIDNEY TUBULAR CELL: ADENOMA 1/50 5/50 24/50
MAY HAVE BEEN RELATED: THYROID GLAND FOLLICULAR CELL: ADENOMA 1/50 2/48 3/50 OR CARCINOMA 0/50 0/48 2/50 COMBINED 1/50 2/48 5/50
HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 5/50 14/50 13/50
NON-NEOPLASTIC LESIONS: KIDNEY: HYPERPLASIA
FR: CLEAR EVIDENCE KIDNEY TUBULAR CELL: ADENOMA 0/50 2/50 5/50
MAY HAVE BEEN RELATED: THYROID GLAND FOLLICULAR CELL: ADENOMA 1/50 1/50 1/50 OR CARCINOMA 0/50 2/50 3/50 COMBINED 1/50 3/50 4/50
HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 16/50 20/50
NON-NEOPLASTIC LESIONS: KIDNEY: HYPERPLASIA
BRAIN: GLIOSIS; HEMORRHAGE; PIGMENTATION; MINERALIZATION
MM: EQUIVOCAL EVIDENCE KIDNEY TUBULAR CELL: ADENOMA 1/50 1/50 3/50
NON-NEOPLASTIC LESIONS: KIDNEY: KARYOMEGALY
FM: EQUIVOCAL EVIDENCE HARDERIAN GLAND: ADENOMA 3/50 7/50 7/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 3/50 8/50 7/50
NON-NEOPLASTIC LESIONS: KIDNEY: KARYOMEGALY

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