Summaries & Associations of Study Results
TR-390 3,3'-Dimethylbenzidine Dihydrochloride
Target Organs and Levels of Evidence
NTP Technical Report Number 390
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 3,3'-DIMETHYLBENZIDINE DIHYDROCHLORIDE 612-82-8 |
04/25/90 | DYE; CHEMICAL INTERMEDIATE FOR AZO DYES; CURING AGENT FOR URETHANE RESINS | Dosed-Water RATS ONLY: 0,30,70,150 PPM (70,45,75,70 PER GROUP RESPECTIVELY) | Hazleton (Vienna) |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | SKIN: BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60 | |||
| ZYMBAL GLAND: ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60 | ||||
| PREPUTIAL GLAND: ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60 | ||||
| LIVER: NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60 | ||||
| ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60 | ||||
| INTESTINES: ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60 | ||||
| MESOTHELIUM (ABDOMINAL CAVITY/TUNICA VAGINALIS): MESOTHELIOMA 0/60 0/45 3/75 4/60 | ||||
| MAY HAVE BEEN RELATED: | BRAIN: GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60 | |||
| NON-NEOPLASTIC LESIONS: | PREPUTIAL GLAND: HYPERPLASIA | |||
| LIVER: CYSTIC DEGENERATION; FOCAL CELLULAR ALTERATIONS | ||||
| LUNG: HYPERPLASIA | ||||
| ZYMBAL GLAND: HYPERPLASIA | ||||
| FR: CLEAR EVIDENCE | SKIN: BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60 | |||
| ZYMBAL GLAND: ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60 | ||||
| CLITORAL GLAND: ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59 | ||||
| LIVER: NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60 | ||||
| ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60 | ||||
| INTESTINES: ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60 | ||||
| MAMMARY GLAND: ADENOCARCINOMA 0/60 1/45 3/75 6/60 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60 | ||||
| MAY HAVE BEEN RELATED: | BRAIN: ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60 | |||
| HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60 | ||||
| NON-NEOPLASTIC LESIONS: | CLITORAL GLAND: HYPERPLASIA | |||
| LIVER: CYSTIC DEGENERATION; FOCAL CELLULAR ALTERATIONS | ||||
| LUNG: HYPERPLASIA | ||||
| ZYMBAL GLAND: HYPERPLASIA | ||||
Web page last updated on February 10, 2006
