Study Results & Research Projects

Summaries & Associations of Study Results

TR-388 Ethylene Thiourea (ETU)

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http://ntp.niehs.nih.gov/go/9134

Target Organs and Levels of Evidence
NTP Technical Report Number 388

Produced from Chemtrack Database 09/19/01

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
ETHYLENE THIOUREA (ETU)
96-45-7 		04/25/90 INTERMEDIATE FOR ANTIOXIDANTS, INSECTICIDES, FUNGICIDES, DYES, PHARMACEUTICALS. ACCELERATOR FOR NEOPRENE, EPICHLOROHYDRIN, AND POLYETHYLENE RUBBERS, DEGRADATION PRODUCT OF CERTAIN FUNGICIDES Dosed-Feed R: 0,25,83,250, M: 0,100,333,1000 PPM/50 PER GROUP Battelle Columbus Laboratory
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: CLEAR EVIDENCE THYROID GLAND FOLLICULAR CELL: ADENOMA 0/49 9/46 23/50 CARCINOMA 1/49 3/46 26/50
NON-NEOPLASTIC LESIONS: THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
FR: CLEAR EVIDENCE THYROID GLAND FOLLICULAR CELL: ADENOMA 1/50 6/44 28/49 CARCINOMA 2/50 1/44 8/49
NON-NEOPLASTIC LESIONS: THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
MM: CLEAR EVIDENCE THYROID GLAND FOLLICULAR CELL: ADENOMA 0/50 1/49 26/50 CARCINOMA 1/50 0/49 5/50
LIVER: ADENOMA 11/49 16/50 9/50; CARCINOMA 13/49 19/50 45/50
PITUITARY GLAND: ADENOMA 0/44 0/42 8/41
NON-NEOPLASTIC LESIONS: THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
LIVER: CYTOMEGALY
PITUITARY GLAND: FOCAL HYPERPLASIA
FM: CLEAR EVIDENCE THYROID GLAND FOLLICULAR CELL: ADENOMA 0/50 2/50 35/50 CARCINOMA 0/50 0/50 8/50
LIVER: ADENOMA 9/50 2/50 33/50; CARCINOMA 2/50 29/50 47/50
PITUITARY GLAND: ADENOMA 10/47 19/49 26/49; CARCINOMA 1/47 0/49 0/49
NON-NEOPLASTIC LESIONS: THYROID GLAND: FOLLICULAR CELL HYPERPLASIA, CYTOPLASMIC VACUOLATION
LIVER: CYTOMEGALY
PITUITARY GLAND: FOCAL HYPERPLASIA

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