Summaries & Associations of Study Results
TR-376 Allyl Glycidyl Ether
Target Organs and Levels of Evidence
NTP Technical Report Number 376
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| ALLYL GLYCIDYL ETHER 106-92-3 |
06/27/89 | STABILIZER OF CHLORINATED COMPOUNDS, VINYL RESINS, RUBBER; RESIN INTERMEDIATE. | Inhalation R&M: 0,5,10 PPM/50 PER GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: EQUIVOCAL EVIDENCE | NASAL CAVITY: ADENOMA 0/44 0/46 1/43; ADENOCARCINOMA 0/44 0/46 1/43; SQUAMOUS CELL CARCINOMA 0/44 0/46 1/43 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: INFLAMMATION 9/44 27/46 18/43; OLFACTORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/44 19/46 35/43; RESPIRATORY EPITHELIUM, HYPERPLASIA 4/44 33/46 30/43; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 4/44 40/46 38/43; OLFACTORY EPITHELIUM, DEGENERATION 0/44 45/46 43/43 | |||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: INFLAMMATION 5/49 7/48 11/47; OLFACTORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 9/48 31/47; RESPIRATORY EPITHELIUM, HYPERPLASIA 1/49 18/48 22/47; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 37/48 38/47; OLFACTORY EPITHELIUM, DEGENERATION 0/49 46/48 47/47 | |||
| MM: SOME EVIDENCE | NASAL CAVITY: ADENOMA 0/50 0/50 3/50 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: INFLAMMATION 2/50 48/50 47/50; OLFACTORY EPITHELIUM, METAPLASIA 4/50 49/50 50/50; RESPIRATORY EPITHELIUM, HYPERPLASIA 0/50 25/50 40/50; RESPIRATORY EPITHELIUM, HYPERPLASIA, BASAL CELL 0/50 1/50 7/50; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/50 4/50 8/50; RESPIRATORY EPITHELIUM, DYSPLASIA 0/50 1/50 3/50 | |||
| FM: EQUIVOCAL EVIDENCE | NASAL CAVITY: ADENOMA 0/49 0/49 1/50 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: INFLAMMATION 8/49 48/49 49/50; OLFACTORY EPITHELIUM, METAPLASIA 7/49 48/49 49/50; RESPIRATORY EPITHELIUM, HYPERPLASIA 0/49 39/49 48/50; RESPIRATORY EPITHELIUM, METAPLASIA, SQUAMOUS 0/49 9/49 12/50; RESPIRATORY EPITHELIUM, HYPERPLASIA, BASAL CELL 0/49 2/49 7/50; RESPIRATORY EPITHELIUM, DYSPLASIA 0/49 0/49 3/50 | |||
Web page last updated on February 10, 2006
