Summaries & Associations of Study Results
TR-370 Benzofuran
Target Organs and Levels of Evidence
NTP Technical Report Number 370
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| BENZOFURAN 271-89-6 |
03/13/89 | MANUFACTURE OF COUMARONE-INDENE RESINS. (TDB) | Gavage FR&MM: 0,60,120, MR: 0,30,60, FM: 0,120,240 MG/KG/50 PER GROUP | Springborn Inst. for Bioresearch, Inc. |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | |||
| FR: SOME EVIDENCE | KIDNEY TUBULAR CELL: ADENOCARCINOMA 0/50 1/50 4/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: NEPHROPATHY 29/50 48/50 39/50 | |||
| PANCREAS: METAPLASIA 0/50 1/50 11/49 | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 4/49 24/39 34/48; HEPATOBLASTOMA 0/49 3/39 18/48; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 9/49 8/39 9/48 COMBINED 12/49 31/39 40/48 | |||
| FORESTOMACH: SQUAMOUS CELL PAPILLOMA 2/49 7/39 10/48 OR SQUAMOUS CELL CARCINOMA 0/49 4/39 3/48 COMBINED 2/49 11/39 13/48 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 7/39 15/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/49 3/39 5/48 COMBINED 10/49 9/39 19/48 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: SYNCYTIAL ALTERATION 4/49 18/39 36/48 | |||
| LUNG: BRONCHIAL EPITHELIAL HYPERPLASIA 3/49 11/39 14/48 | ||||
| FORESTOMACH: EPITHELIAL HYPERPLASIA 16/49 13/39 24/48 | ||||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 1/50 22/48 21/47; HEPATOBLASTOMA 0/50 1/48 2/47; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 3/50 3/48 1/47 COMBINED 4/50 25/48 22/47 | |||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 5/48 13/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/48 3/47 COMBINED 2/50 9/48 14/47 | ||||
| FORESTOMACH: SQUAMOUS CELL PAPILLOMA 2/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 COMBINED 2/50 9/50 5/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: SYNCYTIAL ALTERATION 1/50 0/48 2/47 | |||
| LUNG: BRONCHIAL EPITHELIAL HYPERPLASIA 1/50 22/48 34/47 | ||||
| FORESTOMACH: EPITHELIAL HYPERPLASIA 7/50 19/48 13/47 | ||||
Web page last updated on February 10, 2006
