Summaries & Associations of Study Results
TR-362 4-Vinyl-1-Cyclohexene Diepoxide
Target Organs and Levels of Evidence
NTP Technical Report Number 362
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 4-VINYL-1-CYCLOHEXENE DIEPOXIDE 106-87-6 |
03/13/89 | ORGANIC SYNTHESIS. REACTIVE DILUENT. CHEMICAL INTERMEDIATE. (TDB) | Topical R: 0, 50, 100, M: 0, 25, 50, 100 MG/ML/60 PER GROUP | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | SKIN: BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50 | |||
| FR: CLEAR EVIDENCE | SKIN: BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50 | |||
| MM: CLEAR EVIDENCE | SKIN: SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50 | |||
| FM: CLEAR EVIDENCE | SKIN: SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50 | |||
| OVARY: BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50 | ||||
| MAY HAVE BEEN RELATED: | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 5/50 8/50 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 3/50 1/50 COMBINED 4/50 9/50 11/50 7/50 | |||
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