Summaries & Associations of Study Results
TR-357 Hydrochlorothiazide
Target Organs and Levels of Evidence
NTP Technical Report Number 357
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| HYDROCHLOROTHIAZIDE 58-93-5 |
04/18/88 | DIURETIC FOR HYPERTENSION TREATMENT AND IN VETERINARY MEDICINE. ADJUNCT FOR TREATMENT OF EDEMA. (TDB) | Dosed-Feed R: 0,250,500,2000 PPM/60 PER GROUP, M: 0,2500,5000 PPM/50 PER GROUP | SRI International |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: CHRONIC RENAL DISEASE AND SECONDARY LESIONS | |||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: CHRONIC RENAL DISEASE AND SECONDARY LESIONS | |||
| MM: EQUIVOCAL EVIDENCE | LIVER: ADENOMA 3/48 8/49 14/50 OR CARCINOMA 4/48 4/49 9/50 COMBINED 7/48 10/49 21/50 | |||
| FM: NO EVIDENCE | ||||
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