Summaries & Associations of Study Results
TR-316 Dimethylvinyl Chloride (DMVC)
Target Organs and Levels of Evidence
NTP Technical Report Number 316
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| DIMETHYLVINYL CHLORIDE (DMVC) 513-37-1 |
12/09/85 | CHEMICAL INTERMEDIATE USED IN ORGANIC SYNTHESIS (MERCK 1989) | Gavage 0,100,200 MG/KG/50 PER GROUP | Hazleton Labs, Rockville, Gov't Services, Inc |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | NASAL CAVITY: ADENOCARCINOMA 0/47 8/46 4/32; CARCINOMA 0/47 12/46 24/32; SQUAMOUS CELL CARCINOMA 0/47 3/46 0/32 | |||
| ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 2/50 COMBINED 0/50 5/50 4/50 | ||||
| ESOPHAGUS: SQUAMOUS CELL PAPILLOMA 0/50 2/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/50 4/50 1/49 COMBINED 0/50 6/50 4/49 | ||||
| FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/49 7/50 0/50; SQUAMOUS CELL CARCINOMA 0/49 7/50 0/50 | ||||
| FR: CLEAR EVIDENCE | NASAL CAVITY: ADENOCARCINOMA 0/50 3/49 6/41; CARCINOMA 0/50 11/49 28/41; SQUAMOUS CELL CARCINOMA 0/50 2/49 2/41 | |||
| ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/50 COMBINED 0/50 2/50 5/50 | ||||
| ESOPHAGUS: SQUAMOUS CELL CARCINOMA 0/49 3/50 1/49 | ||||
| FORESTOMACH: SQUAMOUS CELL PAPILLOMA 1/50 4/50 1/49 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 1/49 COMBINED 1/50 9/50 2/49 | ||||
| MM: CLEAR EVIDENCE | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 1/48 3/47 8/44; SQUAMOUS CELL CARCINOMA 0/48 42/47 35/44 | |||
| PREPUTIAL GLAND: SQUAMOUS CELL CARCINOMA 1/48 3/47 16/44 | ||||
| FM: CLEAR EVIDENCE | FORESTOMACH: SQUAMOUS CELL CARCINOMA 0/50 40/47 36/43 | |||
Web page last updated on February 10, 2006
