Summaries & Associations of Study Results
TR-299 C.I. Disperse blue 1
Target Organs and Levels of Evidence
NTP Technical Report Number 299
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| C.I. DISPERSE BLUE 1 2475-45-8 |
03/29/85 | DYE FOR SHEEPSKINS, FURS, THERMOPLASTIC RESINS, ACETATE, NYLON (HSDB 1990); ALSO A COMPONENT OF SEVERAL SEMIPERMANENT HAIR DYES (TR-299, 1986) | Dosed-Feed R: 0,12500,2500,5000, M: 0,600,1200,2500 PPM/50 PER GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | URINARY BLADDER: TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49 | |||
| MAY HAVE BEEN RELATED: | PANCREAS ISLET CELL: ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50 | |||
| NON-NEOPLASTIC LESIONS: | URINARY BLADDER: CALCULI | |||
| FR: CLEAR EVIDENCE | URINARY BLADDER: TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48 | |||
| NON-NEOPLASTIC LESIONS: | URINARY BLADDER: CALCULI | |||
| MM: EQUIVOCAL EVIDENCE | LIVER: ADENOMA 3/50 9/50 10/50 9/50 OR CARCINOMA 6/50 15/50 13/50 8/50 COMBINED 9/50 21/50 20/50 16/50 | |||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/49 5/50 5/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 6/49 1/50 6/50 COMBINED 4/50 9/49 5/50 11/50 | ||||
| FM: NO EVIDENCE | ||||
Web page last updated on February 10, 2006
