Summaries & Associations of Study Results
TR-288 1,3-Butadiene
Target Organs and Levels of Evidence
NTP Technical Report Number 288
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 1,3-BUTADIENE 106-99-0 |
10/28/83 | CHEMICAL INTERMEDIATE. MANUFACTURE OF SYNTHETIC RUBBER. PRODUCED FROM PETROLEUM GASES (MERCK 1989) | Inhalation 0,625,1250 PPM/50 PER GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MM: CLEAR EVIDENCE | HEMATOPOIETIC SYSTEM: LYMPHOMA 0/50 23/50 29/50 | |||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49 | ||||
| FORESTOMACH: PAPILLOMA 0/49 5/40 0/44 | ||||
| VASCULAR SYSTEM (HEART): HEMANGIOSARCOMA 0/50 16/49 7/49 | ||||
| MAY HAVE BEEN RELATED: | ZYMBAL GLAND: CARCINOMA 0/50 0/50 2/50 | |||
| PREPUTIAL GLAND: SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50 | ||||
| BRAIN: GLIOMA 0/50 2/48 1/49 | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: INFLAMMATION, CHRONIC; FIBROSIS; METAPLASIA, CARTILAGINOUS; METAPLASIA, OSSEOUS | |||
| TESTES: ATROPHY | ||||
| FM: CLEAR EVIDENCE | HEMATOPOIETIC SYSTEM: LYMPHOMA 1/50 10/49 10/49 | |||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49 | ||||
| FORESTOMACH: PAPILLOMA 0/49 4/42 10/49 | ||||
| LIVER: ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49 | ||||
| MAMMARY GLAND: ACINAR CELL CARCINOMA 0/50 2/49 6/49 | ||||
| OVARY: GRANULOSA CELL TUMOR 0/49 6/45 12/48 | ||||
| VASCULAR SYSTEM (HEART): HEMANGIOSARCOMA 0/50 11/48 18/49 | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: INFLAMMATION, CHRONIC; FIBROSIS; METAPLASIA, CARTILAGINOUS; METAPLASIA, OSSEOUS | |||
| OVARY: ATROPHY | ||||
Web page last updated on February 10, 2006
