Summaries & Associations of Study Results
TR-269 1,3-Dichloropropene (Telone II)
Target Organs and Levels of Evidence
NTP Technical Report Number 269
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 1,3-DICHLOROPROPENE (TELONE II) 542-75-6 |
07/27/84 | SOIL FUMIGANT, NEMATOCIDE (MERCK 1989) | Gavage R: 0,25,50, M: 0,50,100 MG/KG/50 PER GROUP | Frederick Cancer Research Facility |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 1/52 1/52 9/52; SQUAMOUS CELL CARCINOMA 0/52 0/52 4/52 | |||
| LIVER: NEOPLASTIC NODULE 1/52 6/52 7/52 | ||||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: HYPERPLASIA, EPITHELIAL; HYPERPLASIA, BASAL CELL | |||
| FR: SOME EVIDENCE | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/52 2/52 3/52 | |||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: HYPERPLASIA, EPITHELIAL; HYPERPLASIA, BASAL CELL | |||
| MM: INADEQUATE STUDY | ||||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: HYPERPLASIA, EPITHELIAL | |||
| URINARY BLADDER: HYPERPLASIA, EPITHELIAL | ||||
| FM: CLEAR EVIDENCE | URINARY BLADDER: TRANSITIONAL CELL CARCINOMA 0/50 8/50 21/48 | |||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 8/50 | ||||
| FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 1/50 4/50 | ||||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: HYPERPLASIA, EPITHELIAL | |||
| URINARY BLADDER: HYPERPLASIA, EPITHELIAL | ||||
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