Summaries & Associations of Study Results
TR-209 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Target Organs and Levels of Evidence
NTP Technical Report Number 209
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 2,3,7,8-TETRACHLORODIBENZO-P- DIOXIN 1746-01-6 |
06/27/80 | PRESENT IN CERTAIN HERBICIDE AND FUNGICIDE FORMULATIONS, SUCH AS 2,4,5-T AND PENTACHLOROPHENOLS; IT HAS BEEN TESTED FOR USE IN FLAMEPROOFING POLYESTERS & AGAINST INSECTS AND WOOD-DESTROYING FUNGI. A CONTAMINANT CREATED IN THE MFR OF AGENT ORANGE. | Gavage R&MM: 0,.01,.05,.5 UG/KG/WK/50 PER GROUP FM: 0,.04,.2,2.0 UG/KG/WK/50 PER GROUP | IIT Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: POSITIVE | THYROID GLAND FOLLICULAR CELL: ADENOMA 1/69 5/48 6/50 10/50 | |||
| FR: POSITIVE | LIVER: NEOPLASTIC NODULE 5/75 1/49 3/50 12/49 | |||
| MM: POSITIVE | LIVER: CARCINOMA 8/73 9/49 8/49 17/50 | |||
| FM: POSITIVE | LIVER: CARCINOMA 1/73 2/50 2/48 6/47 | |||
| THYROID GLAND FOLLICULAR CELL: ADENOMA 0/69 3/50 1/47 5/46 | ||||
Web page last updated on February 10, 2006
