Inclusion Criteria:

• Suspected or certain neurally-mediated syncope, based on the Guidelines recently published by the Task Force on Syncope of the European Society of Cardiology 2,3 (Appendix 1);
• More than 3 syncope episodes in the last 2 years;
• Clinical presentation of syncope of sufficient severity requiring treatment initiation in the physician's and patient's judgement.
• Age > 40 years.
• Negative carotid sinus massage.
• Patients accept to have an ILR implantation.

Exclusion criteria:

• Carotid sinus hypersensitivity
• Suspected or certain heart disease and high likelihood of cardiac syncope:
• Symptomatic orthostatic hypotension diagnosed by standing blood pressure measurement;
• Loss of consciousness different from syncope (e.g. epilepsy, psychiatric, metabolic, drop-attack, TIA, intoxication, cataplexy);
• Subclavian steal syndrome;
• Psychologically or physically (due to any other illness) or cognitively unfit for participation in the study according to the opinion of the investigator;
• Patient compliance doubtful;
• Patient geographically or otherwise inaccessible for follow-up;
• Patient unwilling or unable to give informed consent;
• Life expectancy <1 year.