The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

This study is currently recruiting participants.

Verified by University of Alabama at Birmingham, April 2008

Sponsored by:	University of Alabama at Birmingham
Information provided by:	University of Alabama at Birmingham
ClinicalTrials.gov Identifier:	NCT00358306

Purpose

To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Condition
Acute Renal Failure Chronic Kidney Failure Endothelial Dysfunction Hemolytic-Uremic Syndrome (HUS)

MedlinePlus related topics: Kidney Failure

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Cross-Sectional
Official Title:	The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

Further study details as provided by University of Alabama at Birmingham:

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

Estimated Enrollment:	40
Study Start Date:	April 2008
Estimated Study Completion Date:	July 2009

Groups/Cohorts
a those with previous history of Acute kidney injury

Detailed Description:

This research study is designed to study what happens to the kidneys after they have an injury. There is some evidence that even if there appears to be great improvement of kidney function, an injury can put patients at risk for long-term problems with their kidney function and increase their risk to have high blood pressure. We want to collect information from participants to help explain why this injury can cause future problems, including Chronic Kidney Disease (CKD) which may help us prevent these health problems.

Eligibility

Ages Eligible for Study:	2 Years to 20 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Children 2-20 years old with history of acute kidney injury

Criteria

Inclusion Criteria:

Children between age 2-20
Decrease in renal function by 25% or greater
Renal function has returned to normal

Exclusion Criteria:

History of chronic disease
Cancer
Congenital heart disease
Organ Transplantation
Liver disease
Pulmonary disease
Diabetes other primary metabolic condition
Severe neurologic impairments
Hypertension
Auto-immune
Infectious disease or renal disease
Smokers
Renal disease w/primary cause i.e. - HUS or Glomerulonephritis
severe allergies including allergy to seafood and/or iodine

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00358306

Contacts

Contact: Michelle Sharbono

205-558-2792

michelle.sharbono@chsys.org

Locations

United States, Alabama
Pediatric Nephrology	Recruiting
Birmingham, Alabama, United States, 35294
Contact: Michelle Sharbono 205-558-2792 michelle.sharbono@chsys.org

Sponsors and Collaborators

University of Alabama at Birmingham

Investigators

Principal Investigator:

David Askenazi, MD

UAB Pediatric Nephrology

More Information

Responsible Party:	UAB ( David Askenazi M.D. )
Study ID Numbers:	F070309010
Study First Received:	July 28, 2006
Last Updated:	April 4, 2008
ClinicalTrials.gov Identifier:	NCT00358306
Health Authority:	United States: Institutional Review Board

Keywords provided by University of Alabama at Birmingham:

Endothelium
Chronic Kidney Disease
Acute Kidney Injury
Hemolytic-uremic syndrome (HUS)

Study placed in the following topic categories:

Renal Insufficiency
Hemolytic-uremic syndrome
Hematologic Diseases
Blood Platelet Disorders
Kidney Failure, Chronic
Disease Progression
Anemia
Anemia, Hemolytic
Hemolytic-Uremic Syndrome

Thrombocytopathy
Thrombocytopenia
Urologic Diseases
Renal Insufficiency, Chronic
Uremia
Renal Insufficiency, Acute
Kidney Diseases
Kidney Failure, Acute
Kidney Failure

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome

ClinicalTrials.gov processed this record on January 16, 2009