EGRP News Flash - April 18, 2008
FAQs Available About Administrative Supplements for Gene
Identification Efforts
Last month, the Epidemiology and Genetics Research Program
(EGRP) announced the availability of administrative supplements
for NIH-funded genetic association studies aimed at identifying
genetic factors involved in complex trait etiology. A set of Frequently
Asked Questions and Answers for applicants is now available.
Requests for supplements are due by May 1, 2008.
All current NIH awardees of
R01, P01, and P50 grants, and U01, U19, and U54 cooperative agreements
are eligible provided specific conditions are met. This opportunity
is part of the NIH-wide Genes,
Environment, and Health Initiative (GEI), in which
all NIH Institutes and Centers participate.
The supplements are to provide support for replication studies
(with or without fine-mapping) of genetic regions putatively associated
with the studied complex trait(s) (primarily those identified by
genome-wide association studies (GWAS)) in order to maximize the
productivity of NIH-funded GWAS.
Priority funding will be given
to studies with one of more of the following characteristics: synergy
with NIH’s Gene Environment
Association Studies, breadth of available phenotypic and exposure
measures for study participants, and plans for sharing data with
the research community. Studies should focus on replication in
the original discovery population if little replication information
is available to date. If the original “hit” has been
sufficiently replicated, studies should focus on populations not
included in the initial GWAS or subsequent replication studies,
such as groups with different environmental exposures.
Budget
requests must not exceed $400,000 in total costs for funding not
to exceed 12 months. Please note that the NIH Center for Scientific
Review (CSR) is not involved in receipt and processing of these
requests. NCI's EGRP will receive these administrative supplement
requests. See
instructions.
Contact: Elizabeth Gillanders, Ph.D., Program Director, Host
Susceptibility Factors Branch, EGRP; e-mail: lgilland@mail.nih.gov
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