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Volume 1(3);  December 2004
Editorial
A New Vision for Clinical Trials in Africa
The PLoS Medicine Editors
PLoS Med. 2004 December; 1(3): e71. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010071.
PMCID: PMC539056
Synopses
Imaging Lymph Nodes with Nanoparticles
PLoS Med. 2004 December; 1(3): e67. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010067.
PMCID: PMC539053
Sleep Duration Affects Appetite-Regulating Hormones
PLoS Med. 2004 December; 1(3): e68. Published online 2004 December 7. doi: 10.1371/journal.pmed.0010068.
PMCID: PMC535702
Cancer in Families
PLoS Med. 2004 December; 1(3): e69. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010069.
PMCID: PMC539054
Treatment Interruptions in Chronic HIV Infection
PLoS Med. 2004 December; 1(3): e70. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010070.
PMCID: PMC539055
The PLoS Medicine Debate
Is It Ethical to Use Enhancement Technologies to Make Us Better than Well?
Arthur Caplan and Carl Elliott
PLoS Med. 2004 December; 1(3): e52. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010052.
PMCID: PMC539045
Essays
Preserving Creativity in Medicine
David A Shaywitz and Dennis A Ausiello
PLoS Med. 2004 December; 1(3): e34. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010034.
PMCID: PMC539041
The Commercialisation of Medical and Scientific Reporting
Timothy Caulfield
PLoS Med. 2004 December; 1(3): e38. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010038.
PMCID: PMC539042
A Taxpayer-Funded Clinical Trials Registry and Results Database
Erick H Turner
PLoS Med. 2004 December; 1(3): e60. Published online 2004 November 30. doi: 10.1371/journal.pmed.0010060.
PMCID: PMC531613
Neglected Diseases
Finding Cures for Tropical Diseases: Is Open Source an Answer?
Stephen M Maurer, Arti Rai, and Andrej Sali
PLoS Med. 2004 December; 1(3): e56. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010056.
PMCID: PMC539047
Perspectives
Containing the Threat—Don't Forget Ebola
Jonathan Cohen
PLoS Med. 2004 December; 1(3): e59. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010059.
PMCID: PMC539049
Sleep, Appetite, and Obesity—What Is the Link?
Patricia Prinz
PLoS Med. 2004 December; 1(3): e61. Published online 2004 December 7. doi: 10.1371/journal.pmed.0010061.
PMCID: PMC535424
Health in Action
Picturing AIDS: Using Images to Raise Community Awareness
Edwin Mapara and David Morley
PLoS Med. 2004 December; 1(3): e43. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010043.
PMCID: PMC539044
Policy Forum
Strengthening the Role of Genomics in Global Health
Tara Acharya, Abdallah S Daar, Halla Thorsteinsdóttir, Elizabeth Dowdeswell, and Peter A Singer
PLoS Med. 2004 December; 1(3): e40. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010040.
PMCID: PMC539043
Human Carrying Capacity and Human Health
Colin D Butler
PLoS Med. 2004 December; 1(3): e55. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010055.
PMCID: PMC539046
Research in Translation
Pancreatic Islet Transplantation
Mark A Naftanel and David M Harlan
PLoS Med. 2004 December; 1(3): e58. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010058.
PMCID: PMC539048
Research Articles
Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index
Shahrad Taheri, Ling Lin, Diane Austin, Terry Young, and Emmanuel Mignot
PLoS Med. 2004 December; 1(3): e62. Published online 2004 December 7. doi: 10.1371/journal.pmed.0010062.
PMCID: PMC535701
Randomized, Controlled Trial of Therapy Interruption in Chronic HIV-1 Infection
Emmanouil Papasavvas, Jay R Kostman, Karam Mounzer, Robert M Grant, Robert Gross, Cele Gallo, Livio Azzoni, Andrea Foulkes, Brian Thiel, Maxwell Pistilli, Agnieszka Mackiewicz, Jane Shull, and Luis J Montaner
PLoS Med. 2004 December; 1(3): e64. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010064.
PMCID: PMC539050
Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family
Laufey T Amundadottir, Sverrir Thorvaldsson, Daniel F Gudbjartsson, Patrick Sulem, Kristleifur Kristjansson, Sigurdur Arnason, Jeffrey R Gulcher, Johannes Bjornsson, Augustine Kong, Unnur Thorsteinsdottir, and Kari Stefansson
PLoS Med. 2004 December; 1(3): e65. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010065.
PMCID: PMC539051
Sensitive, Noninvasive Detection of Lymph Node Metastases
Mukesh G Harisinghani and Ralph Weissleder
PLoS Med. 2004 December; 1(3): e66. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010066.
PMCID: PMC539052
Correction
Correction: Nevirapine and Efavirenz Elicit Different Changes in Lipid Profiles in Antiretroviral-Therapy-Naive Patients Infected with HIV-1
PLoS Med. 2004 December; 1(3): e73. Published online 2004 December 28. doi: 10.1371/journal.pmed.0010073.
PMCID: PMC539057
Corrects: Frank van Leth, et al. Nevirapine and Efavirenz Elicit Different Changes in Lipid Profiles in Antiretroviral- Therapy-Naive Patients Infected with HIV-1. PLoS Med. 2004 October; 1(1): e19.
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