Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Emory University Duke University University of Toronto |
---|---|
Information provided by: | Emory University |
ClinicalTrials.gov Identifier: | NCT00746421 |
Quetiapine has been reported to have beneficial cognitive effects in several randomized controlled trials in schizophrenia. It has not yet been studied in bipolar disorder, but promising results from the use of extended release quetiapine for the maintenance treatment of bipolar disorder suggests that its cognitive benefits could be detected. Moreover, quetiapine has been shown to have direct beneficial effects on performance-based measures of social competence in schizophrenia and to improve quality of life (QoL) in bipolar depression. The investigators propose to study quetiapine augmentation of mood stabilizer monotherapy in clinically stable patients with bipolar disorder. This will be a randomized, placebo controlled trial, with attentional impairments as the primary outcome and other cognitive performance variables and measures of social and everyday living skills, as well as subjective QoL, as the secondary outcomes.
Condition | Intervention | Phase |
---|---|---|
Bipolar Disorder Cognitive Impairment |
Device: quetiapine XR |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study |
Estimated Enrollment: | 100 |
Study Start Date: | September 2008 |
Estimated Study Completion Date: | December 2010 |
Estimated Primary Completion Date: | September 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
1: Experimental
Quetiapine XR 200-400 mg/day
|
Device: quetiapine XR
oral doses, 200 mg, 300 mg, 400 mg
|
2: Placebo Comparator
Placebo one pill per day matching 200, 300, or 400 mg active medications
|
Device: quetiapine XR
oral doses, 200 mg, 300 mg, 400 mg
|
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
A patient with Diabetes Mellitus (DM) fulfilling one of the following criteria:
Contact: Feea R Leifker, MPH | 404 727 3704 | fleifke@emory.edu |
United States, Georgia | |
Emory University School of Medicine | |
Atlanta, Georgia, United States, 30322 |
Principal Investigator: | Philip D Harvey, PhD | Emory University |
Responsible Party: | Emory University ( Philip D. Harvey, PI ) |
Study ID Numbers: | IRB00009874 |
Study First Received: | September 3, 2008 |
Last Updated: | September 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00746421 |
Health Authority: | United States: Institutional Review Board |
Cognition attention bipolar disability |
Quetiapine Affective Disorders, Psychotic Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Bipolar Disorder |
Mood Disorders Psychotic Disorders Dementia Cognition Disorders Delirium |
Tranquilizing Agents Pathologic Processes Disease Therapeutic Uses Physiological Effects of Drugs |
Psychotropic Drugs Central Nervous System Depressants Antipsychotic Agents Central Nervous System Agents Pharmacologic Actions |