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The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease
This study is currently recruiting participants.
Verified by National Taiwan University Hospital, June 2007
Sponsored by: National Taiwan University Hospital
Information provided by: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00494975
  Purpose

The purpose of this study was to confirm the efficacy of NB UVB phototherapy in alleviating uremic pruritus and investigate the association between improvement of pruritus and change of serum parameters, including routine biochemical data, immune profile and dialysis adequacy.


Condition Intervention
Uremic Pruritus
Device: narrow band UVB

MedlinePlus related topics: Itching
U.S. FDA Resources
Study Type: Interventional
Study Design: Treatment, Randomized, Single Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • Visual Analogue Scale for pruritus [ Time Frame: The investigator will determine the pruritic intensity at baseline, every 3 sessions by VAS score, and by detailed questionnaire at baseline and after 18 sessions ]

Study Start Date: May 2007
Estimated Study Completion Date: December 2007
Detailed Description:

We would conduct a randomized study to evaluate the effect of NB UVB therapy on uremic pruritus. The intensity of pruritus will be evaluated using visual analog scale (VAS) score (0 [no pruritus]-10 most severe pruritus]) and a detailed questionnaire assessing various characteristics of pruritus at baseline . The patients with the intensity of pruritus VAS score more than 5 will be randomized to narrow band UVB and control group. Phototherapy was administered to the whole body surface 2-3 sessions per week for total 18 sessions in a UV irradiation cubicle. The dose increased from 210mJ/cm2 .Doses were increased by 10 % at every session. The control group received time-matched exposures to long-wave ultraviolet light. The investigator will determine the pruritic intensity at baseline every 3 sessions by VAS score and by detailed questionnaire at baseline and after 18 sessions. The blood sample will also be collected at baseline and after treatment to determine factors associated with improvement.

  Eligibility

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Chronic kidney disease with moderate to severe uremic pruritus for longer than 2 months

Exclusion Criteria:

  • pregnancy history of photosensitivity photo-aggravated disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00494975

Contacts
Contact: Mei-Ju Ko, MD 88655323911 kmjmay@gmail.com

Locations
Taiwan, Yunlin County
Department of dermatology, National Taiwan Univeristy Hospital Yun-Lin branch Recruiting
Douliou City, Yunlin County, Taiwan, 640
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Mei-Ju Ko, MD Nationa l Taiwan University Hospital Yun-Lin branch
  More Information

Study ID Numbers: 200704019R
Study First Received: June 29, 2007
Last Updated: June 29, 2007
ClinicalTrials.gov Identifier: NCT00494975  
Health Authority: Taiwan: Department of Health

Study placed in the following topic categories:
Pruritus
Signs and Symptoms
Skin Diseases
Renal Insufficiency, Chronic
Kidney Failure, Chronic
Kidney Diseases

Additional relevant MeSH terms:
Skin Manifestations

ClinicalTrials.gov processed this record on January 16, 2009